AUTHOR=Zhang Xudong , Li Qianming , Wang Zhengxi , Zhou Wei , Zhang Linlin , Liu Yingsheng , Xu Ze , Li Zheng , Zhu Chen , Zhang Xianzuo TITLE=Bone regeneration materials and their application over 20 years: A bibliometric study and systematic review JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.921092 DOI=10.3389/fbioe.2022.921092 ISSN=2296-4185 ABSTRACT=
Bone regeneration materials (BRMs) bring us new sights into the clinical management bone defects. With advances in BRMs technologies, new strategies are emerging to promote bone regeneration. The aim of this study was to comprehensively assess the existing research and recent progress on BRMs, thus providing useful insights into contemporary research, as well as to explore potential future directions within the scope of bone regeneration therapy. A comprehensive literature review using formal data mining procedures was performed to explore the global trends of selected areas of research for the past 20 years. The study applied bibliometric methods and knowledge visualization techniques to identify and investigate publications based on the publication year (between 2002 and 2021), document type, language, country, institution, author, journal, keywords, and citation number. The most productive countries were China, United States, and Italy. The most prolific journal in the BRM field was