AUTHOR=Kurishima Hiroaki , Mori Yu , Ishii Keiko , Inoue Hiroyuki , Mokudai Takayuki , Fujimori Satoko , Itoi Eiji , Hanada Shuji , Masahashi Naoya , Aizawa Toshimi 

TITLE=Antibacterial Activity of an Anodized TiNbSn Alloy Prepared in Sodium Tartrate Electrolyte

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.883335

DOI=10.3389/fbioe.2022.883335

ISSN=2296-4185

ABSTRACT=<p>In this study, we anodized a TiNbSn alloy with low Young’s modulus in an electrolyte of sodium tartrate with and without hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>). The photo-induced characteristics of the anodized alloy were analyzed for crystallinity and electrochemical conditions with comparisons to the effect with the addition of H<sub>2</sub>O<sub>2</sub>. The antibacterial activity was evaluated using methicillin-resistant <italic>Staphylococcus aureus</italic> and other pathogenic bacteria according to ISO 27447, and time decay antibacterial tests were also conducted. The anodized oxide had a porous microstructure with anatase- and rutile-structured titanium dioxide (TiO<sub>2</sub>). In contrast, the peaks of rutile-structured TiO<sub>2</sub> were accelerated in the anodized TiNbSn alloy with H<sub>2</sub>O<sub>2</sub>. The formation of hydroxyl radicals and methylene blue breaching performance under ultraviolet irradiation was confirmed in the anodic oxide on TiNbSn alloy with and without H<sub>2</sub>O<sub>2</sub>. The anodic oxide on TiNbSn alloy had a robust antibacterial activity, and no significant difference was detected with or without H<sub>2</sub>O<sub>2</sub>. We conclude that anodized TiNbSn alloy with sodium tartrate electrolyte may be a functional biomaterial with a low Young’s modulus and an antibacterial function.</p>