AUTHOR=Zhang Hanyuan , Xu Jianxiang , Zhang Xu , Wang Teng , Zhou Dairan , Shu Wei , Zhao Tingting , Fang Weijun 

TITLE=One-Pot Synthesis of Ag/Quaternary Ammonium Salt Co-Decorated Mesoporous Silica Nanoparticles for Synergistic Treatment of Cancer and Bacterial Infections

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.875317

DOI=10.3389/fbioe.2022.875317

ISSN=2296-4185

ABSTRACT=<p>Developing drug delivery nanosystems with both anticancer and antibacterial effects is of great clinical value. Herein, we report a facile approach to synthesize Ag and quaternary ammonium salt (QAS) co-decorated mesoporous silica nanoparticles (MSNs), namely, Ag/QAS-MSNs, for synergistic treatment <ext-link ext-link-type="uri" xlink:href="https://link.springer.com/article/10.1007/s40843-017-9025-3" xmlns:xlink="http://www.w3.org/1999/xlink">of cancer and bacterial infection</ext-link>s. <italic>In vitro</italic> studies demonstrated that Ag/QAS-MSNs not only had a strong antibacterial activity against the bacterial pathogens but also could efficiently induce cancer cell death through an apoptotic pathway. Moreover, <italic>in vivo</italic> combination therapy with Ag and QAS in Ag/QAS-MSNs was also tested in a nude mouse tumor model, and a significant synergistic anticancer effect, which is superior to that obtained by therapy with Ag-MSNs or QAS-MSNs alone, was achieved. Such excellent anticancer and antibacterial activity of Ag/QAS-MSNs could be attributed to the synergistic effect of Ag ions and QAS. Thus, Ag/QAS-MSNs have a promising future as potent anticancer agents with high antibacterial performance.</p>