AUTHOR=Xu Rui , Fang Xinnan , Wu Shengqian , Wang Yiyin , Zhong Yi , Hou Ruixia , Zhang Libing , Shao Lei , Pang Qian , Zhang Jian , Cui Xiang , Zuo Rongyue , Yao Liwei , Zhu Yabin TITLE=Development and Prospect of Esophageal Tissue Engineering JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.853193 DOI=10.3389/fbioe.2022.853193 ISSN=2296-4185 ABSTRACT=

Currently, patients with esophageal cancer, especially advanced patients, usually use autologous tissue for esophageal alternative therapy. However, an alternative therapy is often accompanied by serious complications such as ischemia and leakage, which seriously affect the prognosis of patients. Tissue engineering has been widely studied as one of the ideal methods for the treatment of esophageal cancer. In view of the complex multi-layer structure of the natural esophagus, how to use the tissue engineering method to design the scaffold with structure and function matching with the natural tissue is the principle that the tissue engineering method must follow. This article will analyze and summarize the construction methods, with or without cells, and repair effects of single-layer scaffold and multi-layer scaffold. Especially in the repair of full-thickness and circumferential esophageal defects, the flexible design method and the binding force between the layers of the scaffold are very important. In short, esophageal tissue engineering technology has broad prospects and plays a more and more important role in the treatment of esophageal diseases.