AUTHOR=Wang Mian , Deng Yuping , Xie Pusheng , Tan Jinchuan , Yang Yang , Ouyang Hanbin , Zhao Dongliang , Huang Gang , Huang Wenhua TITLE=Optimal Design and Biomechanical Analysis of a Biomimetic Lightweight Design Plate for Distal Tibial Fractures: A Finite Element Analysis JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=Volume 10 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.820921 DOI=10.3389/fbioe.2022.820921 ISSN=2296-4185 ABSTRACT=The treatment of fractures of the distal tibia can be problematic due to the insubstantial soft-tissue covering this part of the anatomy. This study investigates a novel strategy for minimally invasive plate osteosynthesis of distal tibia fractures called bionic low-profile plating. Following the structure of the animal trabecular bone, bionic low-profile plates utilized topological mathematical methods to redesign the material layout of the address area of the internal fixation device to fulfill the desired low-profile design within given working and boundary conditions. The results showed that this method can maintain the same stability of the construct as the original plate after a reduction in the original volume by 30%, and the differences in strain energy of plates and maximum node displacement of constructs between the constructs (redesign plating [RP] construct vs. locked plating [LP] construct) were not statistically significant (P > 0.05). In the safety assessment of the constructs, the peak stress of plates between constructs was found to not be statistically significantly different under a doubled physiological load (P > 0.05). The average stress of the plates’ elements exceeding the allowable stress was analyzed, and no statistically significant differences were found between the two constructs under axial compression stress conditions (P > 0.05). The average stress of the plates’ elements in the redesigned plating construct under torsional stress conditions was 3.08% less than that of the locked plating construct (P < 0.05). Under the double physiological load condition, 89% of the elements of the plate in the redesigned plating construct and 85% of the elements of the plate in the locked plating construct were lower than the maximum safe stress of the plate, which was 410 MPa (secondary allowable stresses)