AUTHOR=Antuña Eduardo , Carlos Bermejo-Millo Juan , Caso-Onzain Enrique , Caso-Peláez Enrique , Potes Yaiza , Coto-Montes Ana TITLE=Removal of Environmental Nanoparticles Increases Protein Synthesis and Energy Production in Healthy Humans JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.800011 DOI=10.3389/fbioe.2022.800011 ISSN=2296-4185 ABSTRACT=

Currently, industrial activity causes the environmental release of nanoparticles that have multiple adverse effects on population health. There is a clear correlation between the increase in particulate air pollution and the increases in mortality and morbidity rates in both adults and children, which demonstrates the toxic effects of these particles. However, the effect of particle removal on healthy individuals is unknown. Thus, in this preliminary study, we showed, for the first time, how the filtering equipment that we used significantly reduced a large amount of nanoparticles in a minimum time and induced a reduction of oxidative damage in healthy individuals of both sexes after 25, 50 and 100 days of exposure. These effects led to increased protein synthesis and enhanced mitochondrial efficiency, thus resulting in a highly significant triggering of ATP synthesis. These results not only provide insight into the chronic effects that environmental nanoparticles have on individuals prior to the development of pathologies but also demonstrate a system capable of reversing nanoparticle toxicity and allowing cellular energy recovery.