AUTHOR=Garshasbi Hamidreza , Salehi Saba , Naghib Seyed Morteza , Ghorbanzadeh Sadegh , Zhang Wei TITLE=Stimuli-responsive injectable chitosan-based hydrogels for controlled drug delivery systems JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.1126774 DOI=10.3389/fbioe.2022.1126774 ISSN=2296-4185 ABSTRACT=

In the last decade, injectable hydrogels have attracted a lot of attention due to their excellent functional properties in the field of drug delivery for precise, non-invasive and focused tissue locations. Therefore, designing drug delivery systems (DDS) responsive to hydrogel stimuli to release a drug to an external stimulus with various advantages, can be very challenging. Due to their biocompatibility, mucosal adhesion, and hemostatic activity, chitosan (Chitosan)-based hydrogels offer a lot of potential for tissue engineering and drug delivery. It can be difficult to manage the structure of these stimuli-responsive CS hydrogels or they may require additional crosslinking agents, such as hydrogels with dual pH and thermo-responsiveness. Therefore, it is crucial to create these hydrogels for medicinal applications.