AUTHOR=Luo Jiajia , Sun Fenglei , Rao Pinhua , Zhu Tonghe , Liu Yonghang , Du Juan , Chen Sihao , Jin Xiangyun , Jin Jiale , Chai Yi TITLE=A poly (glycerol-sebacate-acrylate) nanosphere enhanced injectable hydrogel for wound treatment JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.1091122 DOI=10.3389/fbioe.2022.1091122 ISSN=2296-4185 ABSTRACT=
Wound repair remains a huge clinical challenge, which can cause bleeding, infection, and patient death. In our current research, a bioactive, injectable, multifunctional composite hydrogel doped with nanospheres was prepared with antibacterial and angiogenesis-promoting functions for the treatment of wounds. Amino groups in ε-polylysine (ε-EPL) undergo dynamic Schiff base reaction cross-linking with oxidized hyaluronic acid (OHA), and F127 exhibits unique temperature sensitivity to form an injectable thermosensitive hydrogel (FHE10), which can form a hydrogel to cover the wound at body temperature. Nanospheres (PNs) prepared using poly (glyceryl-sebacate-acrylate) (PGSA) were loaded into hydrogels (FHE10) for promoting wound repair. The prepared FHE10 exhibited rapid gelation, good injectable abilities, and showed resistance to the flourish of