AUTHOR=Deng Xuyang , Wang Danyang , Zhang Dongjie , Sun Ming , Zhou Liying , Wang Yuxi , Kong Xiaowen , Yuan Changqing , Zhou Qihui 

TITLE=Antibacterial quaternary ammonium chitosan/carboxymethyl starch/alginate sponges with enhanced hemostatic property for the prevention of dry socket

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.1083763

DOI=10.3389/fbioe.2022.1083763

ISSN=2296-4185

ABSTRACT=<p>Tooth extraction commonly leads to postoperative wound bleeding, bacterial infection, and even the occurrence of dry socket. Therefore, developing a biomedical material with favorable antibacterial and excellent hemostatic properties to prevent the post-extraction dry socket is necessary. Herein, quaternary ammonium chitosan/ carboxymethyl starch/alginate (ACQ) sponges are developed <italic>via</italic> Ca<sup>2+</sup> cross-linking, electrostatic interaction, and lyophilization methods. The results show that the bio-multifunctional sponges exhibit interconnected porous structures with significant fluid absorption rates and suitable water vapor transmission rates. <italic>In vitro</italic> cellular and hemolysis experiments indicate that the developed sponges have acceptable biocompatibility. Notably, the constructed sponges effectively inhibit the growth of <italic>E. coli</italic>, <italic>S. aureus,</italic> and <italic>C. albicans</italic>, as well as achieve rapid hemostasis in the mouse liver injury and mini-pig tooth extraction models by absorbing blood and promoting red blood cell adhesion. Thus, the created bio-multifunctional sponges show tremendous promise as a hemostatic material for wound management after tooth extraction.</p>