AUTHOR=Zhang Yuxin , Wang Tianchang , Zhang Dahe , Li Jiayi , Yue Xiaokun , Kong Weiqing , Gu Xiaoding , Jiao Zixian , Yang Chi TITLE=Thermosensitive hydrogel loaded with concentrated growth factors promote bone repair in segmental bone defects JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.1039117 DOI=10.3389/fbioe.2022.1039117 ISSN=2296-4185 ABSTRACT=
Treating critical-size bone defects beyond the body’s self-healing capacity is a challenging clinical task. In this study, we investigate the effect of concentrate growth factors (CGFs) loaded Poloxamer 407 hydrogel on the viability and osteogenic differentiation potential of bone marrow mesenchymal stem cells (BMSCs) and reconstruction of critical-size bone defects.