AUTHOR=Wang Naijian , Pei Bing , Yuan Xinyi , Yi Chengxue , Wiredu Ocansey Dickson Kofi , Qian Hua , Mao Fei 

TITLE=Emerging roles of mesenchymal stem cell-derived exosomes in gastrointestinal cancers

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.1019459

DOI=10.3389/fbioe.2022.1019459

ISSN=2296-4185

ABSTRACT=<p>Gastrointestinal tumours are the most common solid tumours, with a poor prognosis and remain a major challenge in cancer treatment. Mesenchymal stem cells (MSC) are multipotent stromal cells with the potential to differentiate into multiple cell types. Several studies have shown that MSC-derived exosomes have become essential regulators of intercellular communication in a variety of physiological and pathological processes. Notably, MSC-derived exosomes support or inhibit tumour progression in different cancers through the delivery of proteins, RNA, DNA, and bioactive lipids. Herein, we summarise current advances in MSC-derived exosomes in cancer research, with particular reference to their role in gastrointestinal tumour development. MSC-derived exosomes are expected to be a novel potential strategy for the treatment of gastrointestinal cancers.</p>