AUTHOR=Yang Youwen , Cai Guoqing , Yang Mingli , Wang Dongsheng , Peng Shuping , Liu Zhigang , Shuai Cijun 

TITLE=Laser Additively Manufactured Iron-Based Biocomposite: Microstructure, Degradation, and In Vitro Cell Behavior

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2021.783821

DOI=10.3389/fbioe.2021.783821

ISSN=2296-4185

ABSTRACT=<p>A too slow degradation of iron (Fe) limits its orthopedic application. In this study, calcium chloride (CaCl<sub>2</sub>) was incorporated into a Fe-based biocomposite fabricated by laser additive manufacturing, with an aim to accelerate the degradation. It was found that CaCl<sub>2</sub> with strong water absorptivity improved the hydrophilicity of the Fe matrix and thereby promoted the invasion of corrosive solution. On the other hand, CaCl<sub>2</sub> could rapidly dissolve once contacting the solution and release massive chloride ion. Interestingly, the local high concentration of chloride ion effectively destroyed the corrosion product layer due to its strong erosion ability. As a result, the corrosion product layer covered on the Fe/CaCl<sub>2</sub> matrix exhibited an extremely porous structure, thus exhibiting a significantly reduced corrosion resistance. Besides, <italic>in vivo</italic> cell testing proved that the Fe/CaCl<sub>2</sub> biocomposite also showed favorable cytocompatibility.</p>