AUTHOR=Chen Jun , Chen Xinyi , Ho Chun Loong 

TITLE=Recent Development of Probiotic Bifidobacteria for Treating Human Diseases

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2021.770248

DOI=10.3389/fbioe.2021.770248

ISSN=2296-4185

ABSTRACT=<p><italic>Bifidobacterium</italic> is a non-spore-forming, Gram-positive, anaerobic probiotic actinobacterium and commonly found in the gut of infants and the uterine region of pregnant mothers. Like all probiotics, <italic>Bifidobacteria</italic> confer health benefits on the host when administered in adequate amounts, showing multifaceted probiotic effects. Examples include <italic>B. bifidum, B. breve,</italic> and <italic>B. longum</italic>, common <italic>Bifidobacterium</italic> strains employed to prevent and treat gastrointestinal disorders, including intestinal infections and cancers. Herein, we review the latest development in probiotic <italic>Bifidobacteria</italic> research, including studies on the therapeutic impact of <italic>Bifidobacterial</italic> species on human health and recent efforts in engineering <italic>Bifidobacterium</italic>. This review article would provide readers with a wholesome understanding of <italic>Bifidobacteria</italic> and its potentials to improve human health.</p>