AUTHOR=Huang Chuangjia , Guan Xiaoling , Lin Hui , Liang Lu , Miao Yingling , Wu Yueheng , Bao Huiqiong , Wu Xiaodan , Shen Ao , Wei Minyan , Huang Jionghua TITLE=Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2021.762956 DOI=10.3389/fbioe.2021.762956 ISSN=2296-4185 ABSTRACT=

Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye approved by the Food and Drug Administration (FDA), has been extensively used as a photoacoustic (PA) probe for PA imaging. However, its practical application is limited by poor photostability in water, rapid body clearance, and non-specificity. Herein, we fabricated a novel biomimetic nanoprobe by coating ICG-loaded mesoporous silica nanoparticles with the cancer cell membrane (namely, CMI) for PA imaging. This probe exhibited good dispersion, large loading efficiency, good biocompatibility, and homologous targeting ability to Hela cells in vitro. Furthermore, the in vivo and ex vivo PA imaging on Hela tumor-bearing nude mice demonstrated that CMI could accumulate in tumor tissue and display a superior PA imaging efficacy compared with free ICG. All these results demonstrated that CMI might be a promising contrast agent for PA imaging of cervical carcinoma.