AUTHOR=Zhang Wenqian , Chen Lang , Xiong Yuan , Panayi Adriana C. , Abududilibaier Abudula , Hu Yiqiang , Yu Chenyan , Zhou Wu , Sun Yun , Liu Mengfei , Xue Hang , Hu Liangcong , Yan Chenchen , Xie Xuedong , Lin Ze , Cao Faqi , Mi Bobin , Liu Guohui TITLE=Antioxidant Therapy and Antioxidant-Related Bionanomaterials in Diabetic Wound Healing JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2021.707479 DOI=10.3389/fbioe.2021.707479 ISSN=2296-4185 ABSTRACT=

Ulcers are a lower-extremity complication of diabetes with high recurrence rates. Oxidative stress has been identified as a key factor in impaired diabetic wound healing. Hyperglycemia induces an accumulation of intracellular reactive oxygen species (ROS) and advanced glycation end products, activation of intracellular metabolic pathways, such as the polyol pathway, and PKC signaling leading to suppression of antioxidant enzymes and compounds. Excessive and uncontrolled oxidative stress impairs the function of cells involved in the wound healing process, resulting in chronic non-healing wounds. Given the central role of oxidative stress in the pathology of diabetic ulcers, we performed a comprehensive review on the mechanism of oxidative stress in diabetic wound healing, focusing on the progress of antioxidant therapeutics. We summarize the antioxidant therapies proposed in the past 5 years for use in diabetic wound healing, including Nrf2- and NFκB-pathway-related antioxidant therapy, vitamins, enzymes, hormones, medicinal plants, and biological materials.