AUTHOR=Li Caiyun , Alam Khorshed , Zhao Yiming , Hao Jinfang , Yang Qing , Zhang Youming , Li Ruijuan , Li Aiying 

TITLE=Mining and Biosynthesis of Bioactive Lanthipeptides From Microorganisms

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2021.692466

DOI=10.3389/fbioe.2021.692466

ISSN=2296-4185

ABSTRACT=<p>Antimicrobial resistance is one of the most serious public health issues in the worldwide and only a few new antimicrobial drugs have been discovered in recent decades. To overcome the ever-increasing emergence of multidrug-resistant (MDR) pathogens, discovery of new natural products (NPs) against MDR pathogens with new technologies is in great demands. Lanthipeptides which are ribosomally synthesized and post-translationally modified peptides (RiPPs) display high diversity in their chemical structures and mechanisms of action. Genome mining and biosynthetic engineering have also yielded new lanthipeptides, which are a valuable source of drug candidates. In this review we cover the recent advances in the field of microbial derived lanthipeptide discovery and development.</p>