AUTHOR=Xu Zhong-jie , Zhou Ying-jie , Wang Jia-hao , Mao Long-fei , Li Wei , Xu Gui-qing 

TITLE=The Synthesis and Antitumor Activity of 1,8-Naphthalimide Derivatives Linked 1,2,3-Triazole

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2021.662432

DOI=10.3389/fbioe.2021.662432

ISSN=2296-4185

ABSTRACT=<p>In this study, acenaphthylene was used as the raw material, and a series of novel 1,8-naphthalimide-1,2,3-triazole derivatives was obtained through oxidation, acylation, alkylation, and click reactions, and subsequently, their anti-tumor activities were tested. After screening, we found that Compound <bold>5e</bold> showed good activity against H1975 lung cancer cells, with the half maximal inhibitory concentration (IC<sub>50</sub>) reaching 16.56 μM.</p>