AUTHOR=Zhang Huifang , Yang Pengpeng , Wang Zhenyu , Li Mengting , Zhang Jie , Liu Dong , Chen Yong , Ying Hanjie 

TITLE=Clostridium acetobutylicum Biofilm: Advances in Understanding the Basis

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2021.658568

DOI=10.3389/fbioe.2021.658568

ISSN=2296-4185

ABSTRACT=<p><italic>Clostridium acetobutylicum</italic> is an important industrial platform capable of producing a variety of biofuels and bulk chemicals. Biofilm of <italic>C. acetobutylicum</italic> renders many production advantages and has been long and extensively applied in fermentation. However, molecular and genetic mechanisms underlying the biofilm have been much less studied and remain largely unknown. Here, we review studies to date focusing on <italic>C. acetobutylicum</italic> biofilms, especially on its physiological and molecular aspects, summarizing the production advantages, cell physiological changes, extracellular matrix components and regulatory genes of the biofilm. This represents the first review dedicated to the biofilm of <italic>C. acetobutylicum</italic>. Hopefully, it will deepen our understanding toward <italic>C. acetobutylicum</italic> biofilm and inspire more research to learn and develop more efficient biofilm processes in this industrially important bacterium.</p>