AUTHOR=Sajjad Wasim , He Feng , Ullah Muhammad Wajid , Ikram Muhammad , Shah Shahid Masood , Khan Romana , Khan Taous , Khalid Ayesha , Yang Guang , Wahid Fazli 

TITLE=Fabrication of Bacterial Cellulose-Curcumin Nanocomposite as a Novel Dressing for Partial Thickness Skin Burn

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2020.553037

DOI=10.3389/fbioe.2020.553037

ISSN=2296-4185

ABSTRACT=<p>The current study aimed to fabricate curcumin-loaded bacterial cellulose (BC-Cur) nanocomposite as a potential wound dressing for partial thickness burns by utilizing the therapeutic features of curcumin and unique structural, physico-chemical, and biological features of bacterial cellulose (BC). Characterization analyses confirmed the successful impregnation of curcumin into the BC matrix. Biocompatibility studies showed the better attachment and proliferation of fibroblast cells on the BC-Cur nanocomposite. The antibacterial potential of curcumin was tested against <italic>Escherichia coli</italic> (<italic>E. coli</italic>), <italic>Pseudomonas aeruginosa</italic> (<italic>P. aeruginosa</italic>), <italic>Salmonella typhimurium</italic> (<italic>S. typhimurium</italic>), and <italic>Staphylococcus aureus</italic> (<italic>S. aureus</italic>). Wound healing analysis of partial-thickness burns in Balb<sup>c</sup> mice showed an accelerated wound closure up to 64.25% after 15 days in the BC-Cur nanocomposite treated group. Histological studies showed healthy granulation tissues, fine re-epithelialization, vascularization, and resurfacing of wound bed in the BC-Cur nanocomposite group. These results indicate that combining BC with curcumin significantly improved the healing pattern. Thus, it can be concluded that the fabricated biomaterial could provide a base for the development of promising alternatives for the conventional dressing system in treating burns.</p>