AUTHOR=McLaughlin James Alastair , Beal Jacob , Mısırlı Göksel , Grünberg Raik , Bartley Bryan A. , Scott-Brown James , Vaidyanathan Prashant , Fontanarrosa Pedro , Oberortner Ernst , Wipat Anil , Gorochowski Thomas E. , Myers Chris J. TITLE=The Synthetic Biology Open Language (SBOL) Version 3: Simplified Data Exchange for Bioengineering JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=8 YEAR=2020 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2020.01009 DOI=10.3389/fbioe.2020.01009 ISSN=2296-4185 ABSTRACT=

The Synthetic Biology Open Language (SBOL) is a community-developed data standard that allows knowledge about biological designs to be captured using a machine-tractable, ontology-backed representation that is built using Semantic Web technologies. While early versions of SBOL focused only on the description of DNA-based components and their sub-components, SBOL can now be used to represent knowledge across multiple scales and throughout the entire synthetic biology workflow, from the specification of a single molecule or DNA fragment through to multicellular systems containing multiple interacting genetic circuits. The third major iteration of the SBOL standard, SBOL3, is an effort to streamline and simplify the underlying data model with a focus on real-world applications, based on experience from the deployment of SBOL in a variety of scientific and industrial settings. Here, we introduce the SBOL3 specification both in comparison to previous versions of SBOL and through practical examples of its use.