AUTHOR=Belk Lucy , Tellisi Nazzar , Macdonald Hamish , Erdem Ahmet , Ashammakhi Nureddin , Pountos Ippokratis TITLE=Safety Considerations in 3D Bioprinting Using Mesenchymal Stromal Cells JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=8 YEAR=2020 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2020.00924 DOI=10.3389/fbioe.2020.00924 ISSN=2296-4185 ABSTRACT=
Three-dimensional (3D) bioprinting has demonstrated great potential for the fabrication of biomimetic human tissues and complex graft materials. This technology utilizes bioinks composed of cellular elements placed within a biomaterial. Mesenchymal stromal cells (MSCs) are an attractive option for cell selection in 3D bioprinting. MSCs can be isolated from a variety of tissues, can pose vast proliferative capacity and can differentiate to multiple committed cell types. Despite their promising properties, the use of MSCs has been associated with several drawbacks. These concerns are related to the