AUTHOR=Patel Gopal , Thakur Neeraj Singh , Kushwah Varun , Patil Mahesh D. , Nile Shivraj Hariram , Jain Sanyog , Banerjee Uttam Chand , Kai Guoyin 

TITLE=Liposomal Delivery of Mycophenolic Acid With Quercetin for Improved Breast Cancer Therapy in SD Rats

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2020.00631

DOI=10.3389/fbioe.2020.00631

ISSN=2296-4185

ABSTRACT=<p>The present study explores the influence of mycophenolic acid (MPA) in combination therapy with quercetin (QC) (impeding MPA metabolic rate) delivered using the liposomal nanoparticles (LNPs). Mycophenolic acid liposome nanoparticles (MPA-LNPs) and quercetin liposome nanoparticles (QC-LNPs) were individually prepared and comprehensively characterized. The size of prepared MPA-LNPs and QC-LNPs were found to be 183 ± 13 and 157 ± 09.8, respectively. The <italic>in vitro</italic> studies revealed the higher cellular uptake and cytotoxicity of combined therapy (MPA-LNPs + QC-LNPs) compared to individual ones. Moreover pharmacokinetics studies in female SD-rat shown higher <italic>T</italic><sub>1</sub><sub>/</sub><sub>2</sub> value (1.94 fold) of combined therapy compared to MPA. Furthermore, <italic>in vivo</italic> anticancer activity in combination of MPA-LNPs and QC-LNPs was also significantly higher related to other treatments groups. The combination therapy of liposomes revealed the new therapeutic approach for the treatment of breast cancer.</p>