AUTHOR=Zhang Caizhe , Hong Kui 

TITLE=Production of Terpenoids by Synthetic Biology Approaches

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2020.00347

DOI=10.3389/fbioe.2020.00347

ISSN=2296-4185

ABSTRACT=<p>Terpenoids are a large family of natural products with remarkable diverse biological functions, and have a wide range of applications as pharmaceuticals, flavors, pigments, and biofuels. Synthetic biology is presenting possibilities for sustainable and efficient production of high value-added terpenoids in engineered microbial cell factories, using <italic>Escherichia coli</italic> and <italic>Saccharomyces cerevisiae</italic> which are identified as well-known industrial workhorses. They also provide a promising alternative to produce non-native terpenes on account of available genetic tools in metabolic engineering and genome editing. In this review, we summarize the recent development in terpenoids production by synthetic biology approaches.</p>