AUTHOR=Reshetnyak Yana K. , Moshnikova Anna , Andreev Oleg A. , Engelman Donald M. TITLE=Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=8 YEAR=2020 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2020.00335 DOI=10.3389/fbioe.2020.00335 ISSN=2296-4185 ABSTRACT=

The advantages of targeted therapy have motivated many efforts to find distinguishing features between the molecular cell surface landscapes of diseased and normal cells. Typically, the features have been proteins, lipids or carbohydrates, but other approaches are emerging. In this discussion, we examine the use of cell surface acidity as a feature that can be exploited by using pH-sensitive peptide folding to target agents to diseased cell surfaces or cytoplasms.