AUTHOR=Terzini Mara , Aldieri Alessandra , Rinaudo Luca , Osella Giangiacomo , Audenino Alberto L. , Bignardi Cristina 

TITLE=Improving the Hip Fracture Risk Prediction Through 2D Finite Element Models From DXA Images: Validation Against 3D Models

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=7

YEAR=2019

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2019.00220

DOI=10.3389/fbioe.2019.00220

ISSN=2296-4185

ABSTRACT=<p>Osteoporotic fracture incidence represents a major social and economic concern in the modern society, where the progressive graying of the population involves an highly increased fracture occurrence. Although the gold standard to diagnose osteoporosis is represented by the T-score measurement, estimated from the Bone Mineral Density (BMD) using Dual-energy X-ray Absorptiometry (DXA), the identification of the subjects at high risk of fracture still remains an issue. From this perspective, the purpose of this work is to investigate the role that DXA-based two-dimensional patient-specific finite element (FE) models of the proximal femur, in combination with T-score, could play in enhancing the risk of fracture estimation. With this aim, 2D FE models were built from DXA images of the 28 post-menopausal female subjects involved. A sideways fall condition was reproduced and a Risk of Fracture (<inline-formula><mml:math id="M1" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mover accent="true"><mml:mrow><mml:mtext>RF</mml:mtext></mml:mrow><mml:mo>^</mml:mo></mml:mover></mml:math></inline-formula>) was computed on the basis of principal strains criteria. The identified <inline-formula><mml:math id="M2" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mover accent="true"><mml:mrow><mml:mtext>RF</mml:mtext></mml:mrow><mml:mo>^</mml:mo></mml:mover></mml:math></inline-formula> was then compared to that derived from the CT-based models developed in a previous study. The 2D and 3D <inline-formula><mml:math id="M3" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mover accent="true"><mml:mrow><mml:mtext>RF</mml:mtext></mml:mrow><mml:mo>^</mml:mo></mml:mover></mml:math></inline-formula> turned out to be significantly correlated (Spearman's ρ = 0.66, <italic>p</italic> &lt; 0.001), highlighting the same patients as those at higher risk. Moreover, the 2D <inline-formula><mml:math id="M4" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mover accent="true"><mml:mrow><mml:mtext>RF</mml:mtext></mml:mrow><mml:mo>^</mml:mo></mml:mover></mml:math></inline-formula> resulted significantly correlated with the T-score (Spearman's ρ = −0.69, <italic>p</italic> &lt; 0.001), and managed to better differentiate osteopenic patients, drawing the attention to some of them. The Hip Structural Analysis (HSA) variables explaining the majority of the variance of the 2D and 3D fracture risk were the same as well, i.e., neck-shaft angle and narrow neck buckling ratio. In conclusion, DXA-based FE models, developable from currently available clinical data, appear promising in supporting and integrating the present diagnostic procedure.</p>