AUTHOR=Zhao Yang , Dunker William , Yu Yi-Tao , Karijolich John 

TITLE=The Role of Noncoding RNA Pseudouridylation in Nuclear Gene Expression Events

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=6

YEAR=2018

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2018.00008

DOI=10.3389/fbioe.2018.00008

ISSN=2296-4185

ABSTRACT=<p>Pseudouridine is the most abundant internal RNA modification in stable noncoding RNAs (ncRNAs). It can be catalyzed by both RNA-dependent and RNA-independent mechanisms. Pseudouridylation impacts both the biochemical and biophysical properties of RNAs and thus influences RNA-mediated cellular processes. The investigation of nuclear-ncRNA pseudouridylation has demonstrated that it is critical for the proper control of multiple stages of gene expression regulation. Here, we review how nuclear-ncRNA pseudouridylation contributes to transcriptional regulation and pre-mRNA splicing.</p>