AUTHOR=Caspeta Luis , Castillo Tania , Nielsen Jens 

TITLE=Modifying Yeast Tolerance to Inhibitory Conditions of Ethanol Production Processes

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=3

YEAR=2015

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2015.00184

DOI=10.3389/fbioe.2015.00184

ISSN=2296-4185

ABSTRACT=<p><italic>Saccharomyces cerevisiae</italic> strains having a broad range of substrate utilization, rapid substrate consumption, and conversion to ethanol, as well as good tolerance to inhibitory conditions are ideal for cost-competitive ethanol production from lignocellulose. A major drawback to directly design <italic>S. cerevisiae</italic> tolerance to inhibitory conditions of lignocellulosic ethanol production processes is the lack of knowledge about basic aspects of its cellular signaling network in response to stress. Here, we highlight the inhibitory conditions found in ethanol production processes, the targeted cellular functions, the key contributions of integrated -omics analysis to reveal cellular stress responses according to these inhibitors, and current status on design-based engineering of tolerant and efficient <italic>S. cerevisiae</italic> strains for ethanol production from lignocellulose.</p>