AUTHOR=Moreno M. Megan , Bain Travaughn C. , Moreno Melissa S. , Carroll Katherine C. , Cunningham Emily R. , Ashton Zoe , Poteau Roby , Subasi Ersoy , Lipkowitz Michael , Subasi Munevver Mine 

TITLE=Identifying Clinical and Genomic Features Associated With Chronic Kidney Disease

JOURNAL=Frontiers in Big Data

VOLUME=3

YEAR=2021

URL=https://www.frontiersin.org/journals/big-data/articles/10.3389/fdata.2020.528828

DOI=10.3389/fdata.2020.528828

ISSN=2624-909X

ABSTRACT=<p>We apply a pattern-based classification method to identify clinical and genomic features associated with the progression of Chronic Kidney disease (CKD). We analyze the African-American Study of Chronic Kidney disease with Hypertension dataset and construct a decision-tree classification model, consisting 15 combinatorial patterns of clinical features and single nucleotide polymorphisms (SNPs), seven of which are associated with slow progression and eight with rapid progression of renal disease among African-American Study of Chronic Kidney patients. We identify four clinical features and two SNPs that can accurately predict CKD progression. Clinical and genomic features identified in our experiments may be used in a future study to develop new therapeutic interventions for CKD patients.</p>