AUTHOR=Sanchis-Segura Carles , Jancic Dragana , Jimenez-Minchan Maria , Barco Angel TITLE=Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses towards morphine- and morphine withdrawal-related cues JOURNAL=Frontiers in Behavioral Neuroscience VOLUME=3 YEAR=2009 URL=https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/neuro.08.030.2009 DOI=10.3389/neuro.08.030.2009 ISSN=1662-5153 ABSTRACT=

To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner. The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place preference and morphine withdrawal-induced conditioned place avoidance. Our experiments thereby support a role for CREB in striatal neurons regulating approach and avoidance responses toward drug-related cues.