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SYSTEMATIC REVIEW article

Front. Behav. Neurosci.
Sec. Motivation and Reward
Volume 18 - 2024 | doi: 10.3389/fnbeh.2024.1435891
This article is part of the Research Topic Brain reward and aversion circuits: progress review on current and future breakthroughs View all 3 articles

Voluntary wheel-running exercise improvement of anxiety or depressive symptoms in different models of depression

Provisionally accepted
Haodi Shen Haodi Shen Xuemei Li Xuemei Li *Junyao Zhai Junyao Zhai Xin Zhang Xin Zhang
  • Beijing Sport University, Beijing, China

The final, formatted version of the article will be published soon.

    The effects of voluntary wheel-running exercise in different rodent models of depression remain unclear, and further research is needed to fully understand the mechanisms underlying these effects.Therefore, this systematic review aimed to evaluate the currently available findings on whether voluntary wheel-running exercise can alleviate depressive symptoms in five different rodent models of depression. The findings of the comprehensive meta-analysis imply that engaging in voluntary wheel-running exercise has a beneficial effect on alleviating depressive symptoms in rodent models that simulate depression.While further research is needed to fully understand the mechanisms and limitations of this intervention future research should aim to conduct larger. Well-designed studies that use standardized protocols and outcome measures. This would help to reduce heterogeneity between studies and improve the overall quality of the evidence base. Additionally, studies should explore the potential mechanisms of action of voluntary wheel-running exercise in treating depression, such as changes in neurotransmitter levels, neuroplasticity, and inflammation.The results suggest that it may hold promise as an adjunctive therapy for depression.

    Keywords: Voluntary wheel-running exercise1, Depression models2, Forced swimming test3, Sucrose preference test4, Elevated plus maze5

    Received: 21 May 2024; Accepted: 27 Sep 2024.

    Copyright: © 2024 Shen, Li, Zhai and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xuemei Li, Beijing Sport University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.