AUTHOR=Fujiyama Tomoyuki , Takenaka Henri , Asano Fuyuki , Miyanishi Kazuya , Hotta-Hirashima Noriko , Ishikawa Yukiko , Kanno Satomi , Seoane-Collazo Patricia , Miwa Hideki , Hoshino Mikio , Yanagisawa Masashi , Funato Hiromasa TITLE=Mice Lacking Cerebellar Cortex and Related Structures Show a Decrease in Slow-Wave Activity With Normal Non-REM Sleep Amount and Sleep Homeostasis JOURNAL=Frontiers in Behavioral Neuroscience VOLUME=16 YEAR=2022 URL=https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2022.910461 DOI=10.3389/fnbeh.2022.910461 ISSN=1662-5153 ABSTRACT=
In addition to the well-known motor control, the cerebellum has recently been implicated in memory, cognition, addiction, and social behavior. Given that the cerebellum contains more neurons than the cerebral cortex and has tight connections to the thalamus and brainstem nuclei, it is possible that the cerebellum also regulates sleep/wakefulness. However, the role of the cerebellum in sleep was unclear, since cerebellar lesion studies inevitably involved massive inflammation in the adjacent brainstem, and sleep changes in lesion studies were not consistent with each other. Here, we examine the role of the cerebellum in sleep and wakefulness using mesencephalon- and rhombomere 1-specific