AUTHOR=Proshin Andrey T. 

TITLE=Comparative Analysis of Dopaminergic and Cholinergic Mechanisms of Sensory and Sensorimotor Gating in Healthy Individuals and in Patients With Schizophrenia

JOURNAL=Frontiers in Behavioral Neuroscience

VOLUME=Volume 16 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2022.887312

DOI=10.3389/fnbeh.2022.887312

ISSN=1662-5153

ABSTRACT=Sensory and sensorimotor gating provide early processing of information under conditions of  rapid oncome of multiple stimuli. Gating  deficiency is observed in various psychopathologies, in particular, in schizophrenia. However, in the general population there is also a significant proportion of people with low filtration rates who do not show a noticeable cognitive decline,  The review article presents a comparative analysis of existing data on the peculiarities of cholinergic and dopaminergic mechanisms associated with lowering gating  in healthy individuals and in patients with schizophrenia. Conclusions are drawn about the differences in gating mechanisms in cohorts with low filtration rates from the population of healthy and in schizophrenia.