AUTHOR=Zafiri Daphne , Duvarci Sevil TITLE=Dopaminergic circuits underlying associative aversive learning JOURNAL=Frontiers in Behavioral Neuroscience VOLUME=16 YEAR=2022 URL=https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2022.1041929 DOI=10.3389/fnbeh.2022.1041929 ISSN=1662-5153 ABSTRACT=

Associative aversive learning enables animals to predict and avoid threats and thus is critical for survival and adaptive behavior. Anxiety disorders are characterized with deficits in normal aversive learning mechanisms and hence understanding the neural circuits underlying aversive learning and memory has high clinical relevance. Recent studies have revealed the dopamine system as one of the key modulators of aversive learning. In this review, we highlight recent advances that provide insights into how distinct dopaminergic circuits contribute to aversive learning and memory.