AUTHOR=Devineni Anita V. , Scaplen Kristin M. 

TITLE=Neural Circuits Underlying Behavioral Flexibility: Insights From Drosophila

JOURNAL=Frontiers in Behavioral Neuroscience

VOLUME=15

YEAR=2022

URL=https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2021.821680

DOI=10.3389/fnbeh.2021.821680

ISSN=1662-5153

ABSTRACT=<p>Behavioral flexibility is critical to survival. Animals must adapt their behavioral responses based on changes in the environmental context, internal state, or experience. Studies in <italic>Drosophila melanogaster</italic> have provided insight into the neural circuit mechanisms underlying behavioral flexibility. Here we discuss how <italic>Drosophila</italic> behavior is modulated by internal and behavioral state, environmental context, and learning. We describe general principles of neural circuit organization and modulation that underlie behavioral flexibility, principles that are likely to extend to other species.</p>