AUTHOR=Ventura Rossella , Cabib Simona , Babicola Lucy , Andolina Diego , Di Segni Matteo , Orsini Cristina 

TITLE=Interactions Between Experience, Genotype and Sex in the Development of Individual Coping Strategies

JOURNAL=Frontiers in Behavioral Neuroscience

VOLUME=15

YEAR=2021

URL=https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2021.785739

DOI=10.3389/fnbeh.2021.785739

ISSN=1662-5153

ABSTRACT=<p>Coping strategies, the first line of defense against adversities, develop through experience. There is consistent evidence that both genotype and sex contribute to the development of dysfunctional coping, leading to maladaptive outcomes of adverse experiences or to adaptive coping that fosters rapid recovery even from severe stress. However, how these factors interact to influence the development of individual coping strategies is just starting to be investigated. In the following review, we will consider evidence that experience, sex, and genotype influence the brain circuits and neurobiological processes involved in coping with adversities and discuss recent results pointing to the specific effects of the interaction between early experiences, genotype, and stress in the development of functional and dysfunctional coping styles.</p>