AUTHOR=Reichel Judith M. , Nissel Sabine , Rogel-Salazar Gabriela , Mederer Anna , Käfer Karola , Bedenk Benedikt T. , Martens Henrik , Anders Rebecca , Grosche Jens , Michalski Dominik , Härtig Wolfgang , Wotjak Carsten T. TITLE=Distinct behavioral consequences of short-term and prolonged GABAergic depletion in prefrontal cortex and dorsal hippocampus JOURNAL=Frontiers in Behavioral Neuroscience VOLUME=8 YEAR=2015 URL=https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2014.00452 DOI=10.3389/fnbeh.2014.00452 ISSN=1662-5153 ABSTRACT=
GABAergic interneurons are essential for a functional equilibrium between excitatory and inhibitory impulses throughout the CNS. Disruption of this equilibrium can lead to various neurological or neuropsychiatric disorders such as epilepsy or schizophrenia. Schizophrenia itself is clinically defined by negative (e.g., depression) and positive (e.g., hallucinations) symptoms as well as cognitive dysfunction. GABAergic interneurons are proposed to play a central role in the etiology and progression of schizophrenia; however, the specific mechanisms and the time-line of symptom development as well as the distinct involvement of cortical and hippocampal GABAergic interneurons in the etiology of schizophrenia-related symptoms are still not conclusively resolved. Previous work demonstrated that GABAergic interneurons can be selectively depleted in adult mice by means of saporin-conjugated anti-vesicular GABA transporter antibodies (SAVAs)