AUTHOR=Grønli Janne , Soule Jonathan , Bramham Clive R.

TITLE=Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress

JOURNAL=Frontiers in Behavioral Neuroscience

VOLUME=7

YEAR=2014

URL=https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2013.00224

DOI=10.3389/fnbeh.2013.00224

ISSN=1662-5153

ABSTRACT=<p>Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic plasticity and cognitive performance. Here, we discuss evidence linking sleep to mechanisms of protein synthesis-dependent synaptic plasticity and synaptic scaling. We then consider how disruption of sleep by acute and chronic stress may impair these mechanisms and degrade sleep function.</p>