AUTHOR=Nieratschker Vanessa , Nöthen Markus M., Rietschel Marcella TITLE=New genetic findings in schizophrenia: is there still room for the dopamine hypothesis of schizophrenia? JOURNAL=Frontiers in Behavioral Neuroscience VOLUME=4 YEAR=2010 URL=https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2010.00023 DOI=10.3389/fnbeh.2010.00023 ISSN=1662-5153 ABSTRACT=
Schizophrenia is a highly heritable disorder, but the identification of specific genes has proven to be a difficult endeavor. Genes involved in the dopaminergic system are considered to be major candidates since the “dopamine hypothesis” of impairment in dopaminergic neurotransmission is one of the most widely accepted hypotheses of the etiology of schizophrenia. The overall findings from candidate studies do provide some support for the “dopamine hypothesis.” However, results from the first systematic genome-wide association (GWA) studies have implicated variants within