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SYSTEMATIC REVIEW article

Front. Audiol. Otol.
Sec. Otology and Neurotology
Volume 2 - 2024 | doi: 10.3389/fauot.2024.1369716

Click-evoked auditory brainstem response is not affected in auditory processing disorder: A meta-analysis systematic review

Provisionally accepted
Akshay Maggu Akshay Maggu 1*Ying Yu Ying Yu 2Tobias Overath Tobias Overath 3
  • 1 University of Connecticut, Storrs, Connecticut, United States
  • 2 Sleep Medicine Center, Stanford Healthcare, Stanford, California, United States
  • 3 Duke University, Durham, North Carolina, United States

The final, formatted version of the article will be published soon.

    Among several controversies surrounding the field of Auditory Processing Disorder (APD), one of the central unresolved topics is the putative neural origin of APD. More specifically, it is debated whether basic sensory auditory neural processes are affected in individuals with APD. The objective of the current study was to understand whether or not basic sensory auditory neural processes at the level of the brainstem are affected in those with APD. We approached this question by conducting a meta-analysis of studies that compared the Auditory Brainstem Response (ABR) to brief non-speech sounds in individuals with vs. without APD. The ultimate criterion for a study to be included in this meta-analysis was the presence of both APD and non-APD groups on whom ABR waves I, III, and V were collected in response to clicks. In order to extract these studies, a list of inclusion and exclusion criteria were employed during our search using Google Scholar and PubMed databases (accessed between March 2021 and July 2023), resulting in the inclusion of 8 studies. From these studies, we retrieved ABR waves I, III, and V peak amplitude and latency measures. Overall, we found no significant differences between those with and without APD on the ABR waves peak latency (wave I: effect size = -0.0365, C.I. = 0.0384; wave III: effect size = -0.0540, C.I. = 0.1417; wave V: effect size = -0.0577, C.I. = 0.1589) and peak amplitude measures (wave I: effect size = 0.0327, C.I. = 0.0473; wave III: effect size = 0.1415, C.I. = 0.1648; wave V: effect size = 0.1281, C.I. = 0.1346). These findings suggest that the click-evoked ABR may not be implicated in those with APD.

    Keywords: click ABR, Auditory processing disorder (APD), APD diagnosis, Electrophysiology, auditory brainstem

    Received: 12 Jan 2024; Accepted: 30 Jul 2024.

    Copyright: © 2024 Maggu, Yu and Overath. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Akshay Maggu, University of Connecticut, Storrs, 06269, Connecticut, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.