AUTHOR=Guo Yeting , Zhang Yumeng , Ying Jianxi , Liu Yan , Zhang Gaiyun , Zhao Yufen 

TITLE=Selection of Amino Acid Chirality Induced by Cyclic Dipeptide Synthesis in Plausible Prebiotic Conditions

JOURNAL=Frontiers in Astronomy and Space Sciences

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/astronomy-and-space-sciences/articles/10.3389/fspas.2022.794932

DOI=10.3389/fspas.2022.794932

ISSN=2296-987X

ABSTRACT=<p>The biological system uses L-amino acids (L-AAs) to construct peptides. The selection of AA chirality in the prebiotic Earth still remains a mystery. Here we report the intrinsic mechanism of AA chiral selection in the formation of prebiotic proline-containing cyclic dipeptide (DKPs). The DKPs were synthesized by equal amounts of L-AA and D-AA with L-Pro that exhibited a clear preference for D-AA as opposed to L-AA. And surprisingly, the L-AA was preferred over D-AA in the mirror-image system with D-Pro. These results indicate that prebiotic DKPs synthesis has a certain selectivity for AA chirality preceded the biological enzymatic catalysis.</p>