AUTHOR=Genchi Giada G. , Rocca Antonella , Marino Attilio , Grillone Agostina , Mattoli Virgilio , Ciofani Gianni TITLE=Hypergravity As a Tool for Cell Stimulation: Implications in Biomedicine JOURNAL=Frontiers in Astronomy and Space Sciences VOLUME=3 YEAR=2016 URL=https://www.frontiersin.org/journals/astronomy-and-space-sciences/articles/10.3389/fspas.2016.00026 DOI=10.3389/fspas.2016.00026 ISSN=2296-987X ABSTRACT=

Gravity deeply influences numerous biological events in living organisms. Variations in gravity values induce adaptive reactions that have been shown to play important roles, for instance in cell survival, growth, and spatial organization. In this paper, we summarize effects of gravity values higher than that one experienced by cells and tissues on Earth, i.e., hypergravity, with particular attention to the nervous and the musculoskeletal systems. Besides the biological consequences that hypergravity induces in the living matter, we will discuss the possibility of exploiting this augmented force in tissue engineering and regenerative medicine, and thus hypergravity significance as a new therapeutic approach both in vitro and in vivo.