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ORIGINAL RESEARCH article

Front. Artif. Intell.
Sec. Medicine and Public Health
Volume 7 - 2024 | doi: 10.3389/frai.2024.1423535

Multitask Connected U-Net: Automatic lung cancer segmentation from CT images using PET knowledge guidance

Provisionally accepted
  • 1 Shenzhen Hospital, Beijing University of Chinese Medicine, Shenzhen, China
  • 2 School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China
  • 3 Traditional Chinese Medicine (Zhong Jing) School, Henan University Of Chinese Medicine, Zhengzhou, Henan Province, China
  • 4 Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
  • 5 School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China
  • 6 Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Lung cancer is a predominant cause of cancer-related mortality worldwide, necessitating precise tumor segmentation of medical images for accurate diagnosis and treatment. However, the intrinsic complexity and variability of tumor morphology pose substantial challenges to segmentation tasks. To address this issue, we propose a multitask connected U-Net model with a teacher-student framework to enhance the effectiveness of lung tumor segmentation.The proposed model and framework integrate PET knowledge into the segmentation process, leveraging complementary information from both CT and PET modalities to improve segmentation performance. Additionally, we implemented a tumor area detection method to enhance tumor segmentation performance. In extensive experiments on four datasets, the average Dice coefficient of 0.56, obtained using our model, surpassed those of existing methods such as Segformer (0.51), Transformer (0.50), and UctransNet (0.43). These findings validate the efficacy of the proposed method in lung tumor segmentation tasks.

    Keywords: lung cancer, CT image, PET/CT, Medical image segmentation, deep learning

    Received: 26 Apr 2024; Accepted: 26 Jul 2024.

    Copyright: © 2024 Wu, Chen, Chen, Wang, Zhang and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhicheng Zhang, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen, 518055, Guangdong Province, China
    Lu Zhou, Traditional Chinese Medicine (Zhong Jing) School, Henan University Of Chinese Medicine, Zhengzhou, Henan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.