AUTHOR=Joiret Marc , Leclercq Marine , Lambrechts Gaspard , Rapino Francesca , Close Pierre , Louppe Gilles , Geris Liesbet TITLE=Cracking the genetic code with neural networks JOURNAL=Frontiers in Artificial Intelligence VOLUME=6 YEAR=2023 URL=https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2023.1128153 DOI=10.3389/frai.2023.1128153 ISSN=2624-8212 ABSTRACT=

The genetic code is textbook scientific knowledge that was soundly established without resorting to Artificial Intelligence (AI). The goal of our study was to check whether a neural network could re-discover, on its own, the mapping links between codons and amino acids and build the complete deciphering dictionary upon presentation of transcripts proteins data training pairs. We compared different Deep Learning neural network architectures and estimated quantitatively the size of the required human transcriptomic training set to achieve the best possible accuracy in the codon-to-amino-acid mapping. We also investigated the effect of a codon embedding layer assessing the semantic similarity between codons on the rate of increase of the training accuracy. We further investigated the benefit of quantifying and using the unbalanced representations of amino acids within real human proteins for a faster deciphering of rare amino acids codons. Deep neural networks require huge amount of data to train them. Deciphering the genetic code by a neural network is no exception. A test accuracy of 100% and the unequivocal deciphering of rare codons such as the tryptophan codon or the stop codons require a training dataset of the order of 4–22 millions cumulated pairs of codons with their associated amino acids presented to the neural network over around 7–40 training epochs, depending on the architecture and settings. We confirm that the wide generic capacities and modularity of deep neural networks allow them to be customized easily to learn the deciphering task of the genetic code efficiently.