AUTHOR=Marcu Ştefan-Bogdan , Tăbîrcă Sabin , Tangney Mark TITLE=An Overview of Alphafold's Breakthrough JOURNAL=Frontiers in Artificial Intelligence VOLUME=5 YEAR=2022 URL=https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2022.875587 DOI=10.3389/frai.2022.875587 ISSN=2624-8212 ABSTRACT=

This paper presents a short summary of the protein folding problem, what it is and why it is significant. Introduces the CASP competition and how accuracy is measured. Looks at different approaches for solving the problem followed by a review of the current breakthroughs in the field introduced by AlphaFold 1 and AlphaFold 2.