AUTHOR=Chan Maria F. , Witztum Alon , Valdes Gilmer TITLE=Integration of AI and Machine Learning in Radiotherapy QA JOURNAL=Frontiers in Artificial Intelligence VOLUME=3 YEAR=2020 URL=https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2020.577620 DOI=10.3389/frai.2020.577620 ISSN=2624-8212 ABSTRACT=

The use of machine learning and other sophisticated models to aid in prediction and decision making has become widely popular across a breadth of disciplines. Within the greater diagnostic radiology, radiation oncology, and medical physics communities promising work is being performed in tissue classification and cancer staging, outcome prediction, automated segmentation, treatment planning, and quality assurance as well as other areas. In this article, machine learning approaches are explored, highlighting specific applications in machine and patient-specific quality assurance (QA). Machine learning can analyze multiple elements of a delivery system on its performance over time including the multileaf collimator (MLC), imaging system, mechanical and dosimetric parameters. Virtual Intensity-Modulated Radiation Therapy (IMRT) QA can predict passing rates using different measurement techniques, different treatment planning systems, and different treatment delivery machines across multiple institutions. Prediction of QA passing rates and other metrics can have profound implications on the current IMRT process. Here we cover general concepts of machine learning in dosimetry and various methods used in virtual IMRT QA, as well as their clinical applications.