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ORIGINAL RESEARCH article

Front. Appl. Math. Stat., 04 January 2024
Sec. Mathematical Biology
This article is part of the Research Topic Mathematical Modeling of Diseases at Population-Level and Cellular-Level View all 6 articles

Pneumonia and COVID-19 co-infection modeling with optimal control analysis

  • 1Department of Mathematics, Mattu University, Mattu, Ethiopia
  • 2Department of Mathematics, Wollega University, Nekemte, Ethiopia
  • 3Department of Mathematics, Mekelle University, Mekelle, Tigray, Ethiopia

In this study, we present a nonlinear deterministic mathematical model for co-infection of pneumonia and COVID-19 transmission dynamics. To understand the dynamics of the co-infection of COVID-19 and pneumonia sickness, we developed and examined a compartmental based ordinary differential equation type mathematical model. Firstly, we showed the limited region and non-negativity of the solution, which demonstrate that the model is biologically relevant and mathematically well-posed. Secondly, the Jacobian matrix and the Lyapunov function are used to illustrate the local and global stability of the equilibrium locations. If the related reproduction numbers R0c, R0p, and R0 are smaller than unity, then pneumonia, COVID-19, and their co-infection have disease-free equilibrium points that are both locally and globally asymptotically stable otherwise the endemic equilibrium points are stable. Sensitivity analysis is used to determine how each parameter affects the spread or control of the illnesses. Moreover, we applied the optimal control theory to describe the optimal control model that incorporates four controls, namely, prevention of pneumonia, prevention of COVID-19, treatment of infected pneumonia and treatment of infected COVID-19. Then the Pontryagin's maximum principle is introduced to obtain the necessary condition for the optimal control problem. Finally, the numerical simulation of optimality system reveals that the combination of treatment and prevention is the most optimal to minimize the diseases.

1 Introduction

An acute respiratory infection of the lung is pneumonia. Its symptoms can vary depending on age, but the most typical ones include exhaustion, chills, chest pain, a fever, and severe shortness of breath. It spreads via direct or indirect contact with an infected person [1]. Every day, at least one child dies every 45 seconds from pneumonia. Due to pneumonia, ~740,000 deaths have occurred since 2019, especially in the developing world, with an estimate of 5,000 deaths per day [2, 3].

COVID-19 is an infectious respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and spreads via (direct or indirect) contact with saliva droplets released from infected people [4, 5]. From the start of the pandemic up until March 2023, more than 6 million deaths and 761 million infections have been reported to the WHO due to COVID-19. In Ethiopia, the first case was reported on March 13, 2020, and up to March 23, 2023, there have been 500,212 confirmed cases of COVID-19 with 7,572 deaths, and total recoveries are 27,638 reported to WHO [6].

Mathematical modeling has a great role in describing the dynamics of infectious diseases [7]. Several mathematical models have been proposed to study the transmission dynamics of COVID-19; see, for example, [814] and the references cited therein. Mathematical models for pneumonia are also extensively studied in Smith et al. [15], Lipsitch [16], Temime et al.[17], Melegaro et al. [18], Lawi et al. [19], Farr et al. [20], Pessoa [21], and Singh and Aneja [22] and references cited therein. Recently, a few scholars studied the coinfection of various diseases in the mathematical literature; for instance, COVID-19 and malaria coinfection [23, 24], SARS-CoV-2 and HBV co-dynamics [25], COVID-19 and TB coinfection [2628], Pneumonia and HIV coinfection [29], pneumonia and malaria coinfection [30] and pneumonia and typhoid coinfection [31] and references cited therein.

But to the best of our knowledge, in all these studies, no work has been done to investigate the co-infection mathematical modeling of COVID-19 and pneumonia dynamics with the application of the optimal control method. So that we used the SIiR (where the subscript i = p, pc, c refers to pneumonia, co-infection, and COVID-19 infection, respectively) model to describe the transmission dynamics of disease with optimal control.

The remaining part of this paper is organized as follows: In Section 2, we formulate a model of co-infection involving ordinary differential equations, which is well analyzed in Section 3. Extension of the model to optimal control strategies in Section 4. Numerical simulations are carried out in Section 5, and finally, the conclusion and future work are in Section 6.

2 Model description and formulation

In this section, we formulate the mathematical model for the co-infection of pneumonia and COVID-19 by subdividing the total population into five compartments: susceptible (S), pneumonia infected (Ip), COVID-19 infected (Ic), pneumonia-COVID-19 coinfected (Ipc), and recovered population from both diseases (R) based on disease status. The disease is transmitted when the susceptible comes into contact with infected individuals, be they COVID-19-infected, pneumonia-infected, or both. We assumed that the susceptible compartment was increased by the recruitment rate of π. However, susceptible populations have the potential to contract pneumonia with a contact rate of β1 from an individual who is infected with pneumonia alone, or they may become co-infected and join the compartment Ip with a force of infection of fp = β1(Ip + Ipc). In a similar way, a susceptible population can get COVID-19 by a contact rate of β2 from a COVID-19 infected only or co-infected with a force of infection of fc = β2(Ic + Ipc) and join the compartment Ic. Moreover, the pneumonia-infected population recovers from the disease at a rate of σ1, while the remaining population either acquires COVID-19 infection with a force of infection of fc and moves to a co-infectious compartment or dies due to the disease, causing a death rate of α1. Similarly, COVID-19-infected individuals recover from the disease at a rate of σ2, while the remaining portion is either affected by pneumonia infection with the force of infection fp and moves to a co-infectious compartment or dies due to the disease-causing death rate of α2. A co-infected population can recover from one infection at a rate of σ and move to an infected compartment belonging to another disease with a probability of ρ or ν or recovering from both disease with a probability of (1 − (ρ+ν)). Recovered individuals from diseases do not guarantee lifelong immunity; hence, the immunity wanes, and the recovered individuals move to the susceptible compartment at a rate of η. In all compartments, the natural death rate is μ. The population dynamics of the compartments shown in the flowchart of Figure 1 can be described by a system

{dSdt=π+ηR(fp+fc+μ)S,dIpdt=fpS+σρIpc(fc+α1+σ1+μ)Ip,dIcdt=fcS++σνIpc(fp+α2+σ2+μ)Ic,dIpcdt=fpIc+fcIp(α3+σ+μ)Ipc,dRdt=σ1Ip+σ2Ic+σ(1(ρ+ν)Ipc(η+μ)R,    (1)

with initial conditions S(0) = S0, Ip(0) = I0p, Ic(0) = I0c, Ipc(0) = I0pc, and R(0) = R0 are non negative.

Figure 1
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Figure 1. The Model's schematic diagram.

2.1 Boundedness of solution

The invariant region is used to determine where the model's solution is constrained.

Theorem 2.1. The region Ω={(S,Ip,Ic,Ipc,R)+5:N(t)πμ} is positively invariant set for the system 1.

Proof. Differentiate the total population N(t) with respect to time t and substituting all state equations from system 1, we obtain

dNdt=π-μN-α1Ip-α2Ic-α3Ipc.

If there is no death due to the COVID-19 and pneumonia disease, we get

dNdtπ-μN.

On integration yields N(t)N(0)e-μt+πμ[1-e-μt]. Evaluating as t → ∞, we get N(t)πμ. Hence, population size is asymptotically constant. Therefore, the model positively invariant region is given by

Ω={(S,Ip,Ic,Ipc,R)+5 :N(t)πμ}.

     

2.2 Nonnegativity of the solutions

Theorem 2.2. If S0 > 0, Ip0 ≥ 0, Ic0 ≥ 0, Ipc0 ≥ 0 and R0 ≥ 0 then all the solution set S(t), Ip(t), Ic(t), Ipc(t), and R(t) are positive for future time.

Proof. To prove this theorem, let as take the first equation from system 1, we have

dSdt=π+ηR-(fp+fc+μ)S.

This equation can be expressed without loss of generality, after eliminating the positive term (π + ηR), as an inequality

dSdt>-(fp+fc+μ)S,

then using separable method of variables and applying integration, the solution of the differentially inequality can be obtained as

S(t)S(0)e-(fp+fc+μ)dt>0,

where S(0) is obtain from initial condition. Since exponential function is always non-negative, the function e-(fp+fc+μ)dt is a non-negative quantity. Hence, we can concluded that S(t) > 0. In similar manner, we obtain

    Ip(t)Ip(0)e-(fc+α1+σ1+μ)dt0,    Ic(t)Ic(0)e-(fp+α2+σ2+μ)dt0,Ipc(t)Ipc(0)e-(α3+σ+μ)dt0,    R(t)Rpc(0)e-(η+μ)dt0.

This proves that the solution of system 1 are positive for all t ≥ 0. Therefore, all the solution sets are positive for future time.     

3 Model analysis

For better understanding the dynamics of co-infection using the proposed model, we first compute the model equilibrium points and then examine the model dynamics around those stationary points. The detailed analysis will be studied by examining the behavior of the sub-models solutions near the equilibrium points for pneumonia, COVID-19, and their coinfection.

3.1 COVID-19 sub-model

The COVID-19 only sub-model is obtained by excluding the pneumonia infection from the co-infection model,

{dSdt=π+ηR-(β2Ic+μ)S,dIcdt=β2IcS-(α2+σ2+μ)Ic,dRdt=σ2Ic-(η+μ)R.    (2)

3.1.1 Disease-free and reproduction number

The disease-free equilibrium (DFE) of the COVID-19 sub-model is obtained by equating all the RHS of Eq. 2 to zero and putting the disease state variable Ic = 0. Therefore, the disease-free equilibrium of Eq. 2 is denoted by Ξ0c and defined as

Ξ0c=(πμ,0,0).

The basic reproduction number of the COVID-19 sub-model is defined as the average number of secondary infections caused by a single COVID-19-infected individual in a susceptible population. It can be obtained using the approach of the next-generation matrix as given in Van den Driessche and Watmough [32]. The basic reproduction number of the COVID-19 sub-model is the spectral radius of the next-generation matrix FV−1, where F is the matrix of new infection terms and V is the matrix of transition terms. That is,

F(Ξ0c)=(πβ2μ),        V(Ξ0c)=(α2+σ2+μ),

and the inverse of V is given by

V-1(Ξ0c)=1α2+σ2+μ.

Therefore,

R0c=πβ2μ(α2+σ2+μ).

3.1.2 Stability of disease-free equilibrium

Theorem 3.1. The DFE is locally asymptotically stable if R0c<1 and unstable if R0c>1.

Proof. We use the Jacobean matrix to examine the local stability of the equilibrium points. The Jacobian matrix of system 2 at the Ξ0c is

JΞ0c=(-μ-πβ2μη0πβ2μ-(α2+σ2+μ)00σ2-(η+μ)),

and the characteristic equation of matrix JΞ0c is

(-μ-λ)(-(η+μ)-λ)(πβ2μ-(α2+σ2+μ)-λ)=0.

Then, the eigenvalues for JΞ0c are

λ1=-π<0,λ2=-(η+μ)<0,λ3=(α2+σ2+μ)(R0c-1).

Thus, λ3 < 0 if R0c<1. Hence, the DFE is locally asymptomatically stable if R0c<1 and otherwise unstable.     

Theorem 3.2. The disease-free equilibrium of the system 2 is globally asymptotically stable if R0c<1 and unstable if R0c>1.

Proof. To prove the global stability of the equilibrium point, we construct the Lyapunov function as

L=KIc,

and differentiating with respect to t gives

dLdt=KdIcdt.

Substituting dIcdt from the system 2, we obtain

dLdt=K(β1IcS-(α2+σ2+μ)) Ic,      K(β1πμ-(α2+σ2+μ)) Ic,      =K(α2+σ2+μ)(β2πμ(α2+σ2+μ)-1) Ic.

Take K=1α2+σ2+μ, then we get

dLdt=(β2πμ(α2+σ2+μ)-1)Ic,      =(R0c-1)Ic,

for SS0β2πμ and dLdt0 for R0c1 and trajectory of the system 2 on which dLdt=0 if and only if Ic = 0. This implies that the only dLdt0 is Ξ0c. Therefore Ξ0c is globally asymptotically stable in Ω by Lasalle's invariance principle.     

3.1.3 Stability of endemic equilibrium

The endemic equilibrium point of COVID-19 sub-model is denoted by Eec=(S*,Ic*,R*) and it occur when the disease persist in the community. To obtain Eec, we equate all the right hand side of Eq. 2 to zero. Then we obtain

S*=α2+σ2+μβ2=πμ1R0c,Ic*=πμ(η+μ)(R0c-1)β2π(η+μ)-ησ2R0c=(η+μ)(R0c-1)κ,R*=πμσ2(R0c-1)β2π(η+μ)-ησ2R0c=σ2(R0c-1)κ,

where,

κ=β2π(η+μ)-ησ2R0cπμ.

Theorem 3.3. The endemic equilibruim point Eec of system 2 is locally asymptotically stable in Ω if R0c>1.

Proof. Recall the Jacobian matrix of the system 2

J=(-β2Ic*-μ-β2S*ηβ2Ic*β2S*-(α2+σ2+μ)00σ2-(η+μ)).

Evaluating the Jacobian matrix J at the endemic equilibrium point Eec, we get following a characteristic polynomial

λ3+aλ2+bλ+c=0,

where

a=μ(α2+σ2+μ)-β2π(η+μ)ησ2-(α2+σ2+μ)(η+μ)-(η+μ),b=μ(α2+σ2+μ)-β2π(η+μ)ησ2-(α2+σ2+μ)(η+μ)(η+μ)+μ(η+μ),c=(α2+σ2+μ)(η+μ)μ   -μ(α2+σ2+μ)-β2π(η+μ)ησ2-(α2+σ2+μ)(η+μ)[(η+μ)(α2+σ2+μ)-ησ2].

The characteristic equation of J(Eec) is more complicated than that of J(Ξ0c). Using Routh-Hurwitz criterion all roots of characteristic polynomial have negative real parts if and only if a > 0, b > 0, c > 0 and ab > c for R0c>1. Hence, the endemic equilibrium Eec is locally asymptotically stable.     

3.1.4 Sensitivity analysis

Sensitivity analysis is used to identify parameters of the system that would have great influence on R0c. To compute, we used the normalized sensitivity index definition as defined in Chitnis et al. [33].

Definition 1. The normalized sensitivity index of a variable, R0c, that depends differentiably on a parameter, u, is defined as

ΛuR0=R0u×uR0,

for u represents all the basic parameters.

The sensitivity analysis for the basic reproduction number of the sub-model parameters given in Eq. 2 using normalized forward sensitivity index of its R0c is given by:

Λβ2R0c=R0cβ2×β2R0c=1,ΛπR0c=R0cπ×πR0c=1,Λα2R0c=R0cα2×α2R0c=-α2α2+σ2+μ,Λσ2R0c=R0cσ2×σ2R0c=-α2α2+σ2+μ,ΛμR0c=R0cμ×μR0c=-(α2+σ2+2μ)α2+σ2+μ.

The sensitivity indices of the basic reproductive number with respect to main parameters are found in Table 1.

Table 1
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Table 1. Sensitivity indices table.

The results demonstrated that, while the other parameters stayed constant, the parameters with a positive sensitivity index enhanced the value of the reproduction number as their values grew. Furthermore, the value of the reproduction number falls if the values of the parameters having negative indices are raised while the values of the other parameters stay the same. Those parameters that have positive indices (β2) have a high impact on expanding the disease in the community if their values are increasing. The basic parameters with negative sensitivity indices (α2, σ2) increase the disease if their values decrease while the other parameters remain constant. However, increasing human mortality rates to combat disease epidemics is unethical, so they are not taken into account in the study of sensitivity analysis.

3.2 Pneumonia sub-model

The Pneumonia only sub-model is obtained by excluding the COVID-19 infection from the coinfection model,

{dSdt=π+ηR-(β1Ip+μ)S,dIpdt=β1IpS-(α1+σ1+μ)Ip,dRdt=σ1Ip-(η+μ)R.    (3)

3.2.1 Disease-free and reproduction number

The disease-free equilibrium (DFE) of the pneumonia sub-model is denoted by Ξ0p and obtained by setting the right-hand side of system 3 to zero and putting Ip = 0, which is given by

Ξ0p=(πμ,0,0).

Using the next-generation matrix approach, the basic reproduction number of pneumonia sub-model is denoted by R0p is

R0p=πβ1μ(α1+σ1+μ).

3.2.2 Stability of disease-free equilibrium

Theorem 3.4. The DFE is locally asymptotically stable if R0p<1 and unstable if R0p>1.

Proof. The Jacobian matrix of system 3 at the Ξ0p is

JΞ0p=(-μ-πβ1μη0πβ1μ-(α1+σ1+μ)00σ1-(η+μ)).

Here, the eigenvalues for JΞ0p are

λ1=-π<0,λ2=-(η+μ)<0,λ3=(α1+σ1+μ)(R0p-1).

Therefore, the DFE is locally asymptomatically stable if R0p<1 and otherwise unstable.     

Theorem 3.5. The disease-free equilibrium of the system 3 is globally asymptotically stable if R0p<1 and unstable if R0p>1.

Proof. To prove the global stability of the equilibrium point we construct the Lyapunov function as

L=MIp,

and differentiating with respect to t gives

dLdt=MdIpdt.

Substituting dIpdt from the system 3, we obtain

dLdt=M(β2IpS-(α1+σ1+μ))Ip,      M(β1πμ-(α1+σ1+μ))Ip,      =M(α1+σ1+μ)(β1πμ(α1+σ1+μ)-1)Ip.

Take M=1α1+σ1+μ, then we get

dLdt=(β1πμ(α1+σ1+μ)-1)Ip,      =(R0p-1)Ip.

for SS0β1πμ and dLdt0 for R0p1 and trajectory of the system 3 on which dLdt=0 if and only if Ip = 0. This implies that the only dLdt0 is Ξ0p. Therefore Ξ0p is globally asymptotically stable in Ω by Lasalle's invariance principle.     

3.2.3 Stability of endemic equilibrium

The endemic equilibrium point of sub-model 3 is denoted by Eep=(S*,Ip*,R*) and it occurs when the disease persist in the community. To obtain it we equate all the model equations 3 to zero. Then we obtain

S*=α1+σ1+μβ1=πμ1R0p,Ip*=μ(α1+σ1+μ)-β1π(η+μ)β1(ησ1-(η+μ)(α1+σ1+μ))=(η+μ)(R0p-1)κ,R*=σ1[μ(α1+σ1+μ)+β1π]β2[ησ1-(η+μ)(α1+σ1+μ)]=σ1(R0p-1)κ,

where,

κ=β1π(η+μ)-σ1ηR0pπμ.

Theorem 3.6. The endemic equilibrium point Eep of system 3 is locally asymptotically stable in Ω if R0p>1.

Proof. The Jacobian of the system 3, is

J=(-β1Ip*-μ-β1S*ηβ1Ip*β1S*-(α1+σ1+μ)00σ1-(η+μ)).

At the endemic equilibrium point Eep, evaluating the Jacobian matrix J and then solving |J − λI| = 0, the characteristic equation is λ3+ψ1λ2+ψ2λ+ψ3=0, where

ψ1=μ(α1+σ1+μ)-β2π(η+μ)ησ1-(α1+σ1+μ)(η+μ)-(η+μ),ψ2=μ(α1+σ1+μ)-β2π(η+μ)ησ1-(α1+σ1+μ)(η+μ)(η+μ)+μ(η+μ),ψ3=(α1+σ1+μ)(η+μ)μ-            μ(α1+σ1+μ)-β2π(η+μ)ησ1-(α1+σ1+μ)(η+μ)            [(η+μ)(α1+σ1+μ)-ησ1].

Using Routh-Hurwitz criterion all roots of characteristic polynomial have negative real parts if and only if ψ1 > 0, ψ2 > 0, ψ3 > 0 and ψ2ψ2 > ψ3 for R0p>1. Hence, the endemic equilibrium Eep is locally asymptotically stable.     

3.2.4 Sensitivity analysis

The sensitivity analysis for the basic reproduction number of the sub-model parameters given in Eq. 3 using normalized forward sensitivity index of its R0p is given by:

Λβ1R0p=R0pβ1×β1R0p=1,ΛπR0p=R0pπ×πR0p=1,Λα1R0p=R0pα1×α1R0p=-α1α1+σ1+μ<0Λσ1R0p=R0pσ1×σ1R0p=-α1α1+σ2+μ<0,ΛμR0p=R0pμ×μR0p=-(α2+σ2+2μ)α2+σ2+μ.

The sensitivity indices of the basic reproductive number with respect to main parameters are found in Table 2.

Table 2
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Table 2. Sensitivity indices table.

The sensitivity indices of the basic reproductive number with respect to main parameters are β1, σ1, and α1. When the values of factors with positive sensitivity indices, especially β1, are raised while the values of the other parameters remain constant, the impact on the spread of the disease is significant. Also those parameters in which their sensitivity indices are negative α2, σ2, and μ have an effect of minimizing the burden of the disease in the community as their values increase.

3.3 Co-infection model

In this subsection, will examine the system 1 without controls from a qualitative perspective.

3.3.1 Disease-free equilibrium and reproduction number

The disease-free equilibrium of the co-infected model is obtained by equating all the right-hand sides of Eq. 1 to zero and then setting zero for all state variables involving infected individuals. Then, solving for the non-infected state variables, we obtain

Ξ0=(πμ,0,0,0,0,0,0).

To obtain the R0, we used the next-generation matrix method [32]. By the principle of this method, system 1 can be written as

  dIpdt=fpS+σρIpc-(ξ1fc+α1+σ1+μ)Ip,  dIcdt=fcS++σνIpc-(ξ2fp+α2+σ2+μ)Ic,dIpcdt=ξ2fpIc+ξ1fcIp-(α3+σ+μ)Ipc.

The transfer matrix are given by

FV-1=(πβ1μ(α1+σ1+μ)0πβ1μ(σ+α1+α2+μ)0πβ2μ(α2+σ2+μ)πβ2μ(σ+α1+α2+μ)000).

Then the eigenvalues of FV-1 are

λ1=πβ1μ(α1+σ1+μ)=R0p,λ2=πβ2μ(α2+σ2+μ)=R0c,λ3=0.

Therefore, the basic reproduction number of the co-infection model is

R0=max{R0p,R0c}.

3.3.2 Local stability of disease-free equilibrium

Theorem 3.7. The DFE is locally asymptotically stable if R0<1 and unstable if R0>1.

The Jacobian matrix of system 1 at the Ξ0 is

J=(π-πβ1μ-πβ2μ-π(β1+β2)μ00η0πβ1μ-A0πβ1μ00000πβ2μ-Bπβ2μ000000-C0000σ10σp-γ-μ0000σ2σ(1-ρ)ν0-δ-μ0000σ(1-ρ)(1-ν)γδ-η-μ),

where A = α1 + σ1 + μ, B = α2 + σ2 + μ, C = α1 + α2 + σ + μ, and then solve |J − λI| = 0, we get

λ1=-π<0,λ2=(α1+σ1+μ)(R0p-1),λ3=(α2+σ2+μ)(R0c-1),λ4=-(α1+α2+σ+μ)<0,λ5=-(γ+μ)<0,λ6=-(δ+μ)<0,λ7=-(η+μ)<0.

Therefore, the DFE is locally asymptomatically stable if R0p<1 and R0c<1, otherwise unstable.

3.3.3 Sensitivity analysis

The normalized sensitivity index definition found in subsection 3.1 was applied in this subsection. Since R0=max{R0p,R0c}, which means that the sensitivity indexes of R0p and R0c are conducted under each sub-model. Therefore, the most important parameter is the one that is stated in each sub-model.

3.4 Impact of Pneumonia on COVID-19 infection

To describe the impact of pneumonia on COVID-19 and vice versa, we express R0p in terms of R0c. Since,

    R0c=πβ2μ(α2+σ2+μ),μ=πβ2R0c(α2+σ2+μ).

Then, substituting the expression for μ into R0p gives

R0p=R0cβ1(α2+σ2+μ)β2(α1+σ1+μ).

To investigate the impact of the two diseases on each other, we did

R0cR0p=β2(α1+σ1+μ)β1(α2+σ2+μ)>0.    (4)

Equation 4 shows that an increase in pneumonia infection in the community will have a positive influence on the spread of COVID-19 pandemic.

4 Extension into optimal control

In this section, to achieve the best intervention strategies, we reconsider the system 1 and formulate an optimal control problem with four control variables u1(t), u2(t), u3(t), and u4(t) where,

1. u1(t) prevention effort of Pneumonia disease,

2. u2(t) prevention effort of COVID-19 disease,

3. u3(t) treatment effort of pneumonia infected individuals, and

4. u4(t) treatment effort of COVID-19 infected individuals.

After incorporating the controls into the coinfection model, we obtain the following optimal control model

{dSdt=π+ηR-[(1-u1)fp+(1-u2)fc+μ]S,dIpdt=(1-u1)fpS+σρIpc-((1-u2)fc+α1+σ1+u3+μ)Ip,dIcdt=(1-u2)fcS+σνIpc-((1-u1)fp+α2+σ2+u4+μ)Ic,dIpcdt=(1-u2)fcIp+(1-u1)fpIc-(α3+σ+u3+u4+μ)Ipc,dRdt=((1-(ν+ρ))σ+u3+u4)Ipc+(σ2+u4)Ic+(σ1+u3)Ip-            (η+μ)R.    (5)

To study the optimal levels of the controls, the control set U is Lebesgue measurable and is defined as

U={ui(t):0ui<1,i=1,,4,0tT}.    (6)

The aim of introducing the control variables is to seek the optimal solution required to minimize the numbers of infected individuals responsible for spreading the novel Corona virus and pneumonia in the population at minimum cost. Hence, the objective functional for this control problem is given by

J=minu0T(c1Ip+c2Ic+c3Ipc+12i=14wiui2)dt    (7)

subject to the terms of the model system 5. The parameters wifori = 1, 2, 3, 4 measure relative cost of the interventions associated with the controls uifori = 1, 2, 3, 4 and the coefficients c1, c2, c3 represents the weight constants corresponding to infected individuals that can be chosen to balance cost factors and is quadratic in the other pieces of literature [34, 35]. Our aim is to minimize the number of infections and costs. Thus, we want to obtain an optimal controls (u1*,u2*,u3*,u4*) in which:

J(u1*,u2*,u3*,u4*)=min{J(u1,u2,u3,u4):uiU}.    (8)

4.1 Existence of optimal controls

In this subsection, we prove the existence of such optimal control functions which minimize the cost function in the finite intervention period.

Theorem 4.1. There exists an optimal control pair (u1*,u2*,u3*,u4*) and corresponding solution vector (S*,Ip*,Ic*,Ipc*,R*) to the control induced state initial value problem 5 that minimizes the cost functional J(u1, u2, u3, u4) over the set of admissible control U 6.

Proof. All the state variable involved in the model are continuously differentiable. Therefore, we need to verify the following four conditions given in Fleming and Rishel [36].

  i. The set of all solutions to Eq. 5 with corresponding control functions in U is nonempty.

 ii. The control set is convex and closed.

iii. The integrand of the objective functional of Eq. 7 is convex.

 iv. The integrand F(t, S, Ip, Ic, Ipc, R, u) in Eq. 7 is convex with respect to control variables and additionally fulfills that F(t, S, Ip, Ic, Ipc, R, u) ≥ g(u), where g is continuous and ‖u−1g(u) → +∞ as ‖u‖ → ∞.

In order to established condition (i), we refer to Picard-Lindelöf existence theorem [37]. If the solutions of the state equations are a prior bounded and if the state equations are continuous and Lipschitz continuous in the state variables, then there is a unique solution corresponding to every admissible control in the given domain. With the result that, if g(t, x, u) is bounded, continuous, and Lipschitz in the state variable, then there exists a unique solution corresponding to every admissible control U. Hence, for any u ∈ U and the state variables, we have

0N(t)πμ,    (9)

and nonempty by model assumption. Furthermore, with the bounded established in 5, clearly, the state system is continuous and bounded. It is possible to show the boundedness of the partial derivative with respect to the state variable, i.e., gx, exists and is finite, which establishes that the system is Lipschitz with respect to the state variables [37]. This shows that the proof of condition (i) is complete.

To prove (ii), consider

U={u4:||u|| 1, ||·||  is an  Euclidean norm}.

Moreover, for any two points y, zU such that y = (y1, y2, y3, y4) and z = (z1, z2, z3, z4). Then for any λ ∈ [0, 1], it follows λyi + (1 − λ)ziUi, i = 1, 2, 3, 4. This implies that the control set U is convex and closed.

Next we verify condition (iii), the integral of the cost function is given by

F(t,x,u)=c1Ip+c2Ic+c3Ipc+12i=14wiui2

where x denotes the state variable and u represents the control variable. To prove condition (iii), we want to prove for any θ ∈ (01) such that,

(1-θ)F(t,x,u)+θF(t,x,v)F(t,x,(1-θ)u+θv),

where,

(1-θ)F(t,x,u)+θF(t,x,v)=c1Ip+c2Ic+c3Ipc+                1-θ2i=14wiui2+θ2i=14wivi2,

and

F(t,x,(1-θ)u+θv)=c1Ip+c2Ic+c3Ipc+12i=14wi((1-θ)ui+θvi)2.

Therefore,

    F(t,x,v)-F(t,x,(1-θ)u+θv)=    1-θ2i=14wiui2+θ2i=14wivi2-12i=14wi((1-θ)ui+θvi)2,=12i=14wi[(1-θ)ui2+θvi2-((1-θ)ui+θvi)2],=12i=14wi(((1-θ)θ)ui-((1-θ)θ)vi)2,=θ(1-θ)2i=14wi(ui-vi)20.

Hence, (1 − θ)F(t, x, u) + θF(t, x, v) ≥ F(t, x, (1 − θ)u + θv). Therefore, F(t, x, u) is convex. This completes the proof.     

4.2 The Hamiltonian and optimality system

By using the principle Pontryagin's Manimum Principle [38], we got the necessary conditions which is satisfied by optimal pairs. Therefore, by this principle, we obtained a Hamiltonian (H) defined as

H=L+N,

where

N=λ1dSdt+λ2dIpdt+λ3dIcdt+λ4dIpcdt+λ5dRdt,

and

L=c1Ip+c2Ic+c3Ipc+12i=14wiui2.

It follows that the system of Eqs 6 and 5 are substituted into a minimize Hamiltonian function with respect to u1*,u2*,u3*,u4*, we obtain

=c1Ip+c2Ic+c3Ipc+12i=14wiui2    +λ1[π+ηR((1u1)fp+(1u2)fc+μ)S]    +λ2[(1u1)fpS+σρIpc((1u2)ξ1fc+α1+σ1+u3+μ)Ip]    +λ3[(1u2)fcS+σνIpc((1u1)ξ2fp+α2+σ2+u4+μ)Ic]    +λ4[(1u2)ξ1fcIp+(1u1)ξ2fpIc(α3+σ+u3+u4+μ)Ipc]    +λ5[((1(ν+ρ))σ+u3+u4)Ipc+(σ2+u4)Ic+(σ1+u3)Ip         (η+μ)R],    (10)

where λi, fori = 1, …, 5 are adjoint variables. Next to obtain the adjoint variables by applying Pontryagin's minimum principle, the following theorem is stated.

Theorem 4.2. For an optimal control set u1*,u2*,u3*,u4* that minimizes J over U, there is an adjoint variables, λi, fori = 1, …, 5 such that:

dλ1dt=(λ1λ2)(1u1)β1(Ip+Ipc)+(λ1λ3)β2(1u2)(Ic+Ipc),dλ2dt=(λ1λ2)β1(1u1)S+(λ2λ4)ξ1β2(1u2)(Ic+Ipc)+(λ3       λ4)(1u1)β1ξ2Ic+(λ2λ5)(σ1+u3)+λ2(α1+μ)c1,dλ3dt=(λ1λ3)(1u2)β2S+(λ2λ4)(1u2)ξ1β2Ip+(λ3λ4)      (1u1)(Ip+Ipc)ξ2β1+(λ3λ5)(σ2+u4)+λ3(α2+μ)c2,dλ4dt=(λ1λ2)(1u1)β1S+(λ1λ3)(1u2)β2S+(λ2λ4)(1u2)ξ1β2Ip      +(λ3λ4)(1u1)ξ2β1Ic+(λ4λ5)(σ+u3+u4)+(λ5λ2)σρ+      (λ5λ3)σνc3,dλ5dt=(λ5λ1)η+λ5μ,    (11)

with the terminal (transversality) conditions

λi(T)=0,   for  i=1,2,,5.    (12)

Furthermore, the optimal controls u1*,u2*,u3*,u4* are represented by

u1*=min{max{0,φ1},1},u2*=min{max{0,φ2},1},u3*=min{max{0,φ3},1},u4*=min{max{0,φ4},1},

where

φ1=(λ2-λ1)(Ip+Ipc)β1S+(λ4-λ3)(Ip+Ipc)Icξ2β1w1,φ2=(λ3-λ1)(Ic+Ipc)β2S+(λ4-λ2)(Ic+Ipc)ξ1β2Ipw2,φ3=(λ2-λ5)Ip+(λ4-λ5)Ipcw3,φ4=(λ3-λ5)Ic+(λ4-λ5)Ipcw4.

Proof. To obtain the form of the adjoint equations we compute the derivative of the Hamiltonian function (H) Eq. 10 with respect to S, Ip, Ic, Ipc, and R respectively. Then, the adjoint or co-state equation obtained are given by

dλ1dt=S=(λ1λ2)(1u1)β1(Ip+Ipc)+(λ1λ3)β2(1u2)(Ic+Ipc),dλ2dt=Ip=(λ1λ2)β1(1u1)S+(λ2λ4)ξ1β2(1u2)(Ic+Ipc)+(λ3        λ4)(1u1)β1ξ2Ic+(λ2λ5)(σ1+u3)+λ2(α1+μ)c1,dλ3dt=Ic=(λ1λ3)(1u2)β2S+(λ2λ4)(1u2)ξ1β2Ip+(λ3λ4)        (1u1)(Ip+Ipc)ξ2β1+(λ3λ5)(σ2+u4)+λ3(α2+μ)c2,dλ4dt=Ipc=(λ1λ2)(1u1)β1S+(λ1λ3)(1u2)β2S+(λ2λ4)        (1u2)ξ1β2Ip+(λ3λ4)(1u1)ξ2β1Ic+(λ4λ5)(σ+u3+u4)+        (λ5λ2)σρ+(λ5λ3)σνc3,dλ5dt=R=(λ5λ1)η+λ5μ,

with transversality conditions.

To obtain the controls value, we compute the partial derivative of Hamiltonian given by

Hui=0,   for  i=1,2,,4.

Obviously, after derivation of Hamiltonian (H) with respect to the controls the result becomes

{Hu1=0=w1u1+(λ1-λ2)(Ip+Ipc)β1S+(λ3-λ4)(Ip+Ipc)Icβ1ξ2,Hu2=0=w2u2+(λ1-λ3)β2(Ic+Ipc)S+(λ2-λ4)ξ1β2(Ic+Ipc),Hu3=0=w3u3+(λ5-λ2)Ip+(λ5-λ4)Ipc,Hu4=0=w4u4+(λ5-λ3)Ic+(λ5-λ4)Ipc.    (13)

Then, solve for (u1, u2, u3, u4), we obtain

{u1*=(λ2-λ1)(Ip+Ipc)β1S+(λ4-λ3)(Ip+Ipc)Icξ2β1w1,u2*=(λ3-λ1)(Ic+Ipc)β2S+(λ4-λ2)(Ic+Ipc)ξ1β2Ipw2,u3*=(λ2-λ5)Ip+(λ4-λ5)Ipcw3,u4*=(λ3-λ5)Ic+(λ4-λ5)Ipcw4.

From boundedness on ui*(t) and minimality condition, we have:

u1*=min{max{0,φ1},1},u2*=min{max{0,φ2},1},u3*=min{max{0,φ3},1},u4*=min{max{0,φ4},1},

where

φ1=(λ2-λ1)(Ip+Ipc)β1S+(λ4-λ3)(Ip+Ipc)Icξ2β1w1,φ2=(λ3-λ1)(Ic+Ipc)β2S+(λ4-λ2)(Ic+Ipc)ξ1β2Ipw2,φ3=(λ2-λ5)Ip+(λ4-λ5)Ipcw3,φ4=(λ3-λ5)Ic+(λ4-λ5)Ipcw4.

This completes the proof of the theorem.     

5 Numerical simulations

In this section, we illustrate numerically the solution of the optimal control problem proposed in system 1 and Table 3. For this purpose, we use the forward-backward sweep method presented in the book of Lenhart and Workman [39].

Table 3
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Table 3. The values of parameters used in the simulations.

To briefly summarize the numerical simulation procedure, first we perform forward fourth order Runge-Kutta scheme to solve system 1 over the interval [0, T] with its initial condition and the transversality conditions λi(T) = 0; i = 1, 2, 3, 4, 5, where T = 35 is simulation time. Incontrary, we use backward fourth order Runge-Kutta scheme to solve system 10 using the current iteration solution of 1. The control is updated by using a convex combination of the previous control and the values computed in the characterizations process. The iteration continuous until the values of the unknowns at the previous iteration are very close to the values of present iteration. To perform the numerical simulation, we assumed the initial population of

(S(0),Ip(0),Ic(0),Ipc(0),R(0))=(5,000,000,550,26,10,400)

The natural death rate is computed as μ=166.71×12 per month, where 66.71 years is the average life expectancy in Ethiopia [40]. The recruitment rate, is then calculated as π = μ × N(0) = 143, 608 per month, where N(0)= 114,961,850.

The cost coefficients corresponding to control variables are estimated to be c1 = 25, c2 = 75, and c3 = 55 the relative importance of reducing the associated classes on the spread of the disease are w1 = 3, w2 = 8, w3 = 7 and w4 = 5. Using all necessary information above, we analysis and compare the numerical results of the effect of controls on the spread of COVID-19 in populations.

1. Scenario A (using combinations of two controls):

-Strategy 1: Applying both the COVID-19 and pneumonia prevention method (u1 ≠ 0, u2 ≠ 0, u3 = 0, u4 = 0).

-Strategy 2: Applying Pneumonia prevention method and treatment for pneumonia (u1 ≠ 0, u2 = 0, u3 ≠ 0, u4 = 0).

-Strategy 3: Applying Pneumonia prevention method and treatment for COVID-19 (u1 ≠ 0, u2 = 0, u3 = 0, u4 ≠ 0).

-Strategy 4: Applying COVID-19 prevention method and treatment for pneumonia (u1 = 0, u2 ≠ 0, u3 ≠ 0, u4 = 0).

-Strategy 5: Applying COVID-19 prevention method and treatment for COVID-19 (u1 = 0, u2 ≠ 0, u3 = 0, u4 ≠ 0).

-Strategy 6: Applying both the Pneumonia and COVID-19 treatment method (u1 = 0, u2 = 0, u3 ≠ 0, u4 ≠ 0).

2. Scenario B (using triple controls)

-Strategy 7: Applying both the Pneumonia and COVID-19 prevention method and treatment for Pneumonia (u1 ≠ 0, u2 ≠ 0, u3 ≠ 0, u4 = 0).

-Strategy 8: Applying both the Pneumonia and COVID-19 prevention and treatment for COVID-19 (u1 ≠ 0, u2 ≠ 0, u3 = 0, u4 ≠ 0).

-Strategy 9: Applying Pneumonia prevention method and, treatment for Pneumonia and COVID-19 (u1 ≠ 0, u2 = 0, u3 ≠ 0, u4 ≠ 0).

-Strategy 10: Applying COVID-19 prevention method, and treatment for both Pneumonia and COVID-19 (u1 = 0, u2 ≠ 0, u3 ≠ 0, u4 ≠ 0).

3. Scenario C (using all controls)

Using all controls means u1 ≠ 0, u2 ≠ 0, u3 ≠ 0, u4 ≠ 0.

5.1 Scenario A

Under Scenario A, we consider combinations of two controls. Numerical simulations are showed in Figures 2AC. Figure 2A shows that controls with prevention and treatment of Pneumonia disease (Strategy 2) have a potential of decreasing the number of pneumonia infected populations. However, a control with treatment effort only for both disease (Strategy 3) takes more time to decrease the number of pneumonia infected populations. From the Figure 2B shows that controls with treatment effort only for both disease (Strategy 6) decreases the number of co-infectious, Pneumonia infectious and COVID-19 infectious population goes down in the specified time. Figure 2C shows that the Strategy 2 and Strategy 6 have more potential to decreasing number of infected individuals under the scenario A. Ingeneral, we conclude that applying an optimized controls can eradicate both diseases from the community in a specified period of time.

Figure 2
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Figure 2. (A–C) Simulations of pneumonia infected, COVID-19 infected and pneumonia with COVID-19 coinfection with applying the strategies under Scenario A.

5.2 Scenario B

Under this scenario, we considered the combinations of three controls. The simulation results from Figure 3A shows that a control with prevention of Pneumonia disease and treatment of both COVID-19 and Pneumonia disease have a potential of decreasing the co-infectious, Pneumonia infectious and COVID-19 infectious populations. From these four strategies, Strategy 9 rapidly reduces the number of co-infectious, Pneumonia infectious and COVID-19 infectious populations. Figure 3B displays as strategy 10 has a great role in decreasing the burden of COVID-19 disease. Also from Figure 3C we can see that as strategy 7 and 9 have a good approach in reducing the number of coinfected populations.

Figure 3
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Figure 3. (A–C) Simulations of pneumonia infected, COVID-19 infected and coinfection with applying Scenario B.

5.3 Scenario C

Under this scenario, we determined the difference between the compartment with control and without control. We considered four controls at the same time. Figure 4A shows that pneumonia infected compartment is rapidly decreased when we apply all controls. Also Figure 4B displays COVID-19 can be eradicated in a short time if we apply all controls. From the Figure 4C, we can see that as coinfected populations with controls are drammatically decreased.

Figure 4
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Figure 4. (A–C) Simulations of Pneumonia infected, COVID-19 infected and the coinfection of Pneumonia and COVID-19 using all four controls.

6 Conclusions

In this paper, we proposed and analyzed a deterministic mathematical model for the co-infection of COVID-19 with pneumonia. The co-infection model is divided into two submodels, namely, the pneumonia-only submodel and the COVID-19-only submodel. The well-posedness of the model was established both in the mathematical and epidemiological sense by showing that all solutions to the model are positive and bound with initial conditions in a certain meaningful set. The equilibrium and basic reproduction numbers are computed for the co-infection model and each submodel independently. The basic reproduction number of the co-infection model is shown to be the greatest of the reproduction numbers of the two sub-models. It is observed that both submodels and the full co-infection models have locally asymptotically stable disease-free equilibrium when their respective basic reproduction numbers are less than unity and otherwise unstable. Furthermore, there exists a stable endemic equilibrium point for the basic reproduction numbers greater than one. A sensitivity analysis of the model was performed and identified the positive and negative index parameters. From the basic model, an optimal control problem is formulated by incorporating two control variables: prevention, treatment, and their combination. The Hamiltonian, adjoint variables, the characterization of the controls and the optimality system are derived from the optimal control problem and also numerically simulated by considering a single control at a time, a combination of two controls at a time, and lastly, by applying all three control variables. Several combinations of the control variables are compared to determine which combination is most effective in the fight against pneumonia and COVID-19.

Data availability statement

The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.

Author contributions

BA: Conceptualization, Data curation, Formal analysis, Investigation, Resources, Validation, Writing—original draft. TK: Supervision, Writing—review & editing. DT: Formal analysis, Software, Validation, Writing—review & editing. HB: Validation, Supervision, Review, Editing.

Funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

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Keywords: pneumonia, COVID-19, coinfection, basic reproduction number, sensitivity analysis, optimal control, numerical simulations

Citation: Aga BZ, Keno TD, Terfasa DE and Berhe HW (2024) Pneumonia and COVID-19 co-infection modeling with optimal control analysis. Front. Appl. Math. Stat. 9:1286914. doi: 10.3389/fams.2023.1286914

Received: 31 August 2023; Accepted: 30 October 2023;
Published: 04 January 2024.

Edited by:

Joseph Malinzi, University of Eswatini, Eswatini

Reviewed by:

Andrew Omame, Government College University, Lahore, Pakistan
Pankaj Tiwari, University of Kalyani, India
Chinwendu Madubueze, Federal University of Agriculture Makurdi (FUAM), Nigeria

Copyright © 2024 Aga, Keno, Terfasa and Berhe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Beza Zeleke Aga, bezeleke48@gmail.com

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.