Effects of Saccharomyces Boulardii Cell Wall Polysaccharide on Growth Performance, Immunity, Antioxidant Ability and Ileal Mucosal Morphology of Jinhua Weaned Piglets in North of Xinjiang Region

Wenshu Zhu ¹ Wantong Ren ¹ Xucheng Mo ² Wenshuai Zen ¹ Mengjian Liu ^1*

• ¹ Xinjiang Agricultural University, Ürümqi, China
• ² Xiniiang Changii National Agricultunal High Tech Industry Demonstration Zone, Changji, China

This study investigates the effects of SBWP on the performance, immune capacity, antioxidant capacity, and mucosal morphology of weaned piglets from Jinhua, North Xinjiang region. Results: Compared to the CON group, the 0.5% and 1.0% SBWP groups demonstrated a increase in average daily feed intake (ADFI) and average daily gain (ADG), alongside a decrease in the feed-to-gain ratio (F/G). Additionally, the average fecal score and diarrhea frequency in the 0.5% and 1.0% SBWP groups were reduced, with no mortality recorded in these groups, which represented a 37.50% reduction compared to the CON group. In terms of ileal mucosal immunity, the 0.5% and 1.0% SBWP supplementation groups demonstrated reduced concentrations of proinflammatory cytokines, including interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), as well as diamine oxidase (DAO). Conversely, both groups exhibited significantly elevated concentrations of the anti-inflammatory cytokine interleukin-10 (IL-10).Furthermore, the addition of 0.5% and 1.0% SBWP significantly increased secretory immunoglobulin A (SIgA). In serum immunity, both SBWP groups had reduced concentrations of TNF-α, IL-1β, IL-6 and DAO. Regarding the antioxidant capacity of the ileal mucosa, the content of malondialdehyde (MDA) and hydrogen peroxide (H2O2) in the 0.5% and 1.0% SBWP groups were decreased, while catalase (CAT), glutathione peroxidase (GSH-Px), and total antioxidant capacity (T-AOC) were increased, and superoxide dismutase (SOD) activity was enhanced. Lastly, the addition of 0.5% and 1.0% SBWP to the basal diet resulted in a promotion in villus height and the ratio of villus height to crypt depth (VCR), thereby improving the morphology of the ileal mucosa. In conclusion, the growth performance of weaned piglets from Jinhua in northern Xinjiang improved by 0.5-1.0% when supplemented with SBWP in the basal diet.