AUTHOR=Kojima Miyu , Liu Hong , Takemoto Satoshi , Suda Yoshihito , Inoue Ryo , Watanabe Gen , Jin Wanzhu , Nagaoka Kentaro TITLE=Temporal changes in the fecal microbiome and blood metabolites of early neonatal calves JOURNAL=Frontiers in Animal Science VOLUME=3 YEAR=2022 URL=https://www.frontiersin.org/journals/animal-science/articles/10.3389/fanim.2022.934204 DOI=10.3389/fanim.2022.934204 ISSN=2673-6225 ABSTRACT=
The initial colonization and early development of the intestinal microbiome are important stages in the growth of calves during pre-weaning. This study investigated temporal changes in the diversity and composition of the fecal microbiota, focusing on the first 2 weeks after birth, with the aim of identifying intestinal bacteria and blood metabolites that are associated with calf diarrhea. In this study, 10 calves were fed colostrum on day 0 after birth, whole milk from days 2 to 5, and milk replacer from day 6. Six calves showed mild diarrhea in the second week (i.e., from day 8 to 14). We observed dramatic changes in the development of the fecal microbiome from day 2 to 14 and found several bacterial species, such as