AUTHOR=Bae Chul-Young , Im Yoori , Lee Jonghoon , Park Choong-Shik , Kim Miyoung , Kwon Hojeong , Kim Boseon , Park Hye ri , Lee Chun-Koo , Kim Inhee , Kim JeongHoon TITLE=Comparison of Biological Age Prediction Models Using Clinical Biomarkers Commonly Measured in Clinical Practice Settings: AI Techniques Vs. Traditional Statistical Methods JOURNAL=Frontiers in Analytical Science VOLUME=1 YEAR=2021 URL=https://www.frontiersin.org/journals/analytical-science/articles/10.3389/frans.2021.709589 DOI=10.3389/frans.2021.709589 ISSN=2673-9283 ABSTRACT=

In this work, we used the health check-up data of more than 111,000 subjects for analysis, using only the data with all 35 variables entered. For the prediction of biological age, traditional statistical methods and four AI techniques (RF, XGB, SVR, and DNN), which are widely used recently, were simultaneously used to compare the predictive power. This study showed that AI models produced about 1.6 times stronger linear relationship on average than statistical models. In addition, the regression analysis on the predicted BA and CA revealed similar differences in terms of both the correlation coefficients (linear model: 0.831, polynomial model: 0.996, XGB model: 0.66, RF model: 0.927, SVR model: 0.787, DNN model: 0.998) and R2 values. Through this work, we confirmed that AI techniques such as the DNN model outperformed traditional statistical methods in predicting biological age.