AUTHOR=Sang Le , Gong Xia , Huang Yunlei , Zhang Linling , Sun Jian TITLE=Immunotherapeutic implications on targeting the cytokines produced in rhinovirus-induced immunoreactions JOURNAL=Frontiers in Allergy VOLUME=5 YEAR=2024 URL=https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2024.1427762 DOI=10.3389/falgy.2024.1427762 ISSN=2673-6101 ABSTRACT=

Rhinovirus is a widespread virus associated with several respiratory diseases, especially asthma exacerbation. Currently, there are no accurate therapies for rhinovirus. Encouragingly, it is found that during rhinovirus-induced immunoreactions the levels of certain cytokines in patients' serum will alter. These cytokines may have pivotal pro-inflammatory or anti-inflammatory effects via their specific mechanisms. Thus far, studies have shown that inhibitions of cytokines such as IL-1, IL-4, IL-5, IL-6, IL-13, IL-18, IL-25, and IL-33 may attenuate rhinovirus-induced immunoreactions, thereby relieving rhinovirus infection. Furthermore, such therapeutics for rhinovirus infection can be applied to viruses of other species, with certain practicability.